{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:39:31Z","timestamp":1782290371953,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":206,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004600","name":"Kyungpook National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease. Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models. We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aortic remodeling in rats under pressure overload\u2010induced by transverse aortic constriction (TAC). The aortic ring tension analysis was conducted using the thoracic aorta. Sections of the aorta were visualized after hematoxylin and eosin, trichrome, and Verhoeff\u2010van Gieson staining, and immunohistochemistry. The expression of genes related to aortic remodeling (<jats:italic>\u03b1SMA<\/jats:italic>, <jats:italic>Mmp2<\/jats:italic>, and <jats:italic>Mmp9<\/jats:italic>) and angiotensin receptors (<jats:italic>Agtr1<\/jats:italic> and <jats:italic>Agtr2<\/jats:italic>) was determined by quantitative real\u2010time polymerase chain reaction. There was a significant decrease in relaxation of the aorta when treated with MGCD. Fibrosis of the aortic wall and expression of angiotensin receptors increased in TAC rats, which was attenuated by MGCD. These results indicate that MGCD, an HDAC inhibitor, attenuates aortic remodeling in rats with TAC\u2010induced pressure overload rats and may serve as a potential therapeutic target of antiaortic remodeling in pressure overload\u2010induced hypertension\u2010related diseases.<\/jats:p>","DOI":"10.1155\/2020\/4705615","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T23:31:02Z","timestamp":1595719862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure 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