{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:38:28Z","timestamp":1747190308296,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2020,1,29]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To report unusual and rare clinical changes of retinal vessel pattern in a series of patients affected by Juvenile Idiopathic Arthritis (JIA) uveitis with a follow-up longer than 16 years. <jats:italic>Methods<\/jats:italic>. A series of three patients with JIA-uveitis followed at the University of Rome \u201cSapienza\u201d from 1998 to 2014 were reported. The retinal vessels were analyzed with fluorescein angiography using Heidelberg Retinal Angiogram-2 (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany) and the Topcon TRC-50LX retinal camera (Topcon Europe, The Netherlands). A Spectralis Domain OCT (SD-OCT) (Spectralis Family Heidelberg, Germany) was performed to evaluate vessel anatomy. <jats:italic>Results<\/jats:italic>. Fundus photography showed sheathed vessels localized around the optic disc in every case. Angiography revealed a normal physiology of vessel walls and flow; no sheathing or leakage of dye was observed. SD-OCT demonstrated reflective vessel walls. Vessel lumen appeared patent, and the normal \u201c<jats:italic>hourglass configuration<\/jats:italic>\u201d was blurred, but identifiable. <jats:italic>Conclusions<\/jats:italic>. Vessel modifications observed in long-standing JIA-uveitis are not signs of vascular inflammation and are not associated to hypoperfusion. In these cases, ophthalmologists should avoid further invasive investigation and should consider introducing SD-OCT as a routine method to evaluate the vessel changes during the follow-up.<\/jats:p>","DOI":"10.1155\/2020\/4720819","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T18:32:18Z","timestamp":1580322738000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Retinal Vessel Modification in Patients Affected by JIA-Uveitis with a Follow-Up Longer Than 16 Years"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-4823","authenticated-orcid":true,"given":"Alessandro","family":"Abbouda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sapienza University, Umberto I Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Abicca","sequence":"additional","affiliation":[{"name":"IRCCS-Fondazione Bietti, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-2693","authenticated-orcid":true,"given":"Simone","family":"Bruschi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sapienza University, Umberto I Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ricci","sequence":"additional","affiliation":[{"name":"UOSD Retinal Pathology PTV Foundation Policlinico Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-1041","authenticated-orcid":true,"given":"Gianluca","family":"Aloe","sequence":"additional","affiliation":[{"name":"UOSD Retinal Pathology PTV Foundation Policlinico Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-4774","authenticated-orcid":true,"given":"Maria Pia","family":"Paroli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sapienza University, Umberto I Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.791701"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem053"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32833eab83"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.01.033"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.025"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.855798"},{"issue":"4","key":"7","first-page":"513","volume":"1","year":"2007","journal-title":"Clinical Ophthalmology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802650398"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/803989"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301023"},{"issue":"12","key":"11","first-page":"2737","volume":"28","year":"2001","journal-title":"The Journal of Rheumatology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(14)74235-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.06.007"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-14-66"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/bf02175446"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313078"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-13903"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4720819.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4720819.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4720819.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T18:32:24Z","timestamp":1580322744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criopm\/2020\/4720819\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":18,"alternative-id":["4720819","4720819"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4720819","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2020,1,29]]}}}