{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:28:17Z","timestamp":1775478497482,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postgraduate Education Innovation Program in Guangdong Province","award":["2020JGXM029"],"award-info":[{"award-number":["2020JGXM029"]}]},{"name":"Postgraduate Education Innovation Program in Guangdong Province","award":["2018GJK019"],"award-info":[{"award-number":["2018GJK019"]}]},{"name":"Educational Science Planning Projects in Guangdong Province","award":["2020JGXM029"],"award-info":[{"award-number":["2020JGXM029"]}]},{"name":"Educational Science Planning Projects in Guangdong Province","award":["2018GJK019"],"award-info":[{"award-number":["2018GJK019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Threatened abortion (TA) is a common complication with high incidence in the first trimester of pregnancy, which will end in miscarriage if not treated properly. The Chinese herbs Cuscutae Semen (Tusizi in Chinese) and Herba Taxilli (Sangjisheng in Chinese) first recorded in the ancient classic medical book <jats:italic>Shennong Bencao Jing<\/jats:italic> are effective and widely used as an herb pair for the treatment of TA, while the active ingredients and the functional mechanism of Tusizi\u2010Sangjisheng herb pair treating TA are still unknown. In order to exploit the relationship between those two herbs and TA, systems pharmacology analysis was carried out in this study. A total of 75 ingredients of Tusizi\u2010Sangjisheng were collected from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). 12 bioactive compounds were screened, and 153 directly related targets were predicted by systematic models. Besides, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to systematically explore the potential mechanisms of Tusizi\u2010Sangjisheng treating TA. Meanwhile, Compound\u2010Target (C\u2010T), Target\u2010Disease (T\u2010D), and Target\u2010Pathway (T\u2010P) networks were constructed to further quest the underlying functional mechanisms of Tusizi\u2010Sangjisheng. As a result, 31 targets and 3 key pathways were found to be directly related to TA that includes mitogen\u2010activated protein kinases (MAPKs), phosphatidylinositol\u20103\u2010kinase\/protein kinase B (PI3K\u2010Akt), and transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic> (TGF\u2010<jats:italic>\u03b2<\/jats:italic>) signaling pathways. The results in this study may provide some valuable clues about the molecular mechanisms of the efficient Chinese herb pair Tusizi\u2010Sangjisheng in the treatment of TA.<\/jats:p>","DOI":"10.1155\/2020\/4748264","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T23:34:34Z","timestamp":1595374474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Systems Pharmacology\u2010Based Research on the Mechanism of Tusizi\u2010Sangjisheng Herb Pair in the Treatment of Threatened Abortion"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-2947","authenticated-orcid":false,"given":"Ming","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghe","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-530X","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.204"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7458.152"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7099.32"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1006618"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.023"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31802f11f6"},{"key":"e_1_2_9_7_2","first-page":"1074","article-title":"Non-surgical interventions for threatened and recurrent miscarriages","volume":"48","author":"Tien J. C.","year":"2007","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002857.pub2"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.904500"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80164-7"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003576.pub2"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000016026"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3616875"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1903069"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009278.pub2"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.18.6.444"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00437"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1979"},{"key":"e_1_2_9_19_2","first-page":"61","article-title":"Research on medication rules of traditional Chinese medicine in treating threatened abortion based on association rule","volume":"32","author":"Dan Z.","year":"2018","journal-title":"Chin. Med. J. Res. Prac"},{"key":"e_1_2_9_20_2","article-title":"Exploration on the medication rules of threatened abortion of famous-aged Chinese doctors based on traditional Chinese medicine inheritance auxiliary platform","volume":"69","author":"Li S.","year":"2019","journal-title":"Beijing university of Chinese medicine"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61354-9"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/150153"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(14)60088-1"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500153"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5107"},{"key":"e_1_2_9_26_2","first-page":"34","article-title":"Flavonoids of Taxillus sutchuenensis (Lecomte) Danser and T. sutchuenensis var. duclouxii (Lecomte) Kiuined","volume":"12","author":"Li M. R.","year":"1987","journal-title":"Zhong yao tong bao (Beijing, China: 1981)"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1190719"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880200802179667"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13066964"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037608"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.016"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701361104"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00167-1"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0530-4"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9340637"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030167"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(17)30008-0"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040975"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197563"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.10.061"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0717788"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.02.045"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3993"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4269"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicines3040029"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0282-1"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0160107"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.09.009"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111839"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69170-7"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2004.09.003"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.06632.x"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.3.h1106"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90324-0"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.12.026"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-003-0547-0"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.06.003"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.02.002"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-119"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-126"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.2.0428"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1042\/bc20040146"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-12-0571"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.03.004"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2016.1216980"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat094"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.025"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6356190"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.170"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28112"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00110"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.010"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27483"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz024"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)00260-9"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5142"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.03.006"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4748264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4748264.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/4748264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:35:19Z","timestamp":1735630519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/4748264"}},"subtitle":[],"editor":[{"given":"Robert J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/4748264"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4748264","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4748264"}}