{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:22:27Z","timestamp":1791652947527,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2018R1D1A1B07040959"],"award-info":[{"award-number":["2018R1D1A1B07040959"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2020,7,13]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson\u2019s disease. <jats:italic>Methods<\/jats:italic>. Between 2003 and 2006, we included 153,165 participants from the national health insurance system-health screening cohort in Korea. The incidence of new-onset Parkinson\u2019s disease was defined as International Classification of Diseases-10 code \u201cG20,\u201d accompanying the prescription records for any anti-Parkinson\u2019s disease medication. <jats:italic>Results<\/jats:italic>. Approximately 19.9% of the included participants had periodontal disease. After a median duration of 10.4 years, 1,227 (0.8%) cases of new-onset Parkinson\u2019s disease were noted. The number of tooth loss was positively related to an increased risk of new-onset Parkinson\u2019s disease. Contrastingly, the frequency of tooth brushings and dental clinic visits for any causes as well as competent dental care were negatively related to the development of new-onset Parkinson\u2019s disease. In multivariable analysis, the number of tooth loss (\u226515) was positively related to new-onset Parkinson\u2019s disease development (hazard ratio: 1.38, 95% confidence interval (1.03\u20131.85), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.029<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><\/mml:math> for trend\u2009=\u20090.043) after adjusting variables. <jats:italic>Conclusion<\/jats:italic>. Our study demonstrated that the number of tooth loss was positively correlated with a higher risk of new-onset Parkinson\u2019s disease development in a longitudinal study setting. Increased number of tooth loss may be an important risk indicator of new-onset Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1155\/2020\/4760512","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:38:04Z","timestamp":1594683484000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["Association of Tooth Loss with New-Onset Parkinson\u2019s Disease: A Nationwide Population-Based Cohort Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Ho Geol","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonkyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University 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