{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:19:19Z","timestamp":1775279959887,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-I2M-1\u2013009"],"award-info":[{"award-number":["2016-I2M-1\u2013009"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2020,7,26]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Circulating levels of cardiac troponin I (cTnI) after ST-segment elevation myocardial infarction (STEMI) were considered as prognostic factors for predicting the incidence of major adverse cardiovascular events (MACE). \u25b3cTnI is the difference between peak cTnI after primary percutaneous coronary intervention (PPCI) and cTnI on initial admission. <jats:italic>Purpose<\/jats:italic>. This study aimed to assess the relationship between \u25b3cTnI, the ratio of \u25b3cTnI to cTnI on initial admission, and the incidence of MACE during the follow-up period. <jats:italic>Methods<\/jats:italic>. A total of 2596 patients with cTnI measured upon admission and one-time measurement of cTnI during hospitalization were enrolled. <jats:italic>Results<\/jats:italic>. In the adjusted models of the survival receiver operating characteristic (ROC) curve, \u25b3cTnI and the ratio of \u25b3cTnI to cTnI on initial admission have stronger discrimination power of MACE (area under curve (AUC) 0.730 and 0.717) compared with peak cTnI after PPCI and cTnI at admission (AUC 0.590, 0.546). Multivariate Cox regression analysis identified \u25b3cTnI (hazard ratio (HR) 1.018, 95% confidence interval (CI) 1.001 to 1.035) as a relevant factor for MACE during follow-up. \u25b3cTnI was divided into quartiles, and maximum \u25b3 cTnI between 4.845 and 19.073\u2009ng\/ml comprised more patients with anterior wall myocardial infarction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><\/mml:math>\u2009&lt;\u20090.001), higher GRACE score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><\/mml:math>\u2009=\u20090.038), CK-MB (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><\/mml:math>\u2009=\u20090.023), and Myoglobin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><\/mml:math>\u2009&lt;\u20090.001). On the K\u2013M survival curves, the incidence of MACE, mortality, and angina pectoris were significantly higher in the group with maximum \u25b3cTnI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><\/mml:math>\u2009=\u20090.035, 0.049, 0.026). <jats:italic>Conclusion<\/jats:italic>. The \u25b3cTnI level and the ratio of \u25b3cTnI have stronger discrimination power of predicting the incidence of MACE. The group with maximum \u25b3cTnI has higher incidence of MACE, mortality, and angina pectoris during the follow-up period.<\/jats:p>","DOI":"10.1155\/2020\/4793178","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T23:30:56Z","timestamp":1595806256000},"page":"1-13","source":"Crossref","is-referenced-by-count":7,"title":["Association between Variation of Troponin and Prognosis of Acute Myocardial Infarction before and after Primary Percutaneous Coronary Intervention"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xiaoxiao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for 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