{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:29Z","timestamp":1787017829902,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"\n Purpose<\/jats:italic>\n . To evaluate medium-term clinical outcomes with XEN\u00ae 45 or XEN\u00ae 63 Gel Stent (Allergan, Dublin, Ireland) for treatment of primary open angle glaucoma (POAG).\n Materials and Methods<\/jats:italic>\n . Retrospective, descriptive, and observational study involving 40 patients implanted with a XEN\u00ae 45 Gel Stent and 34 implanted with a XEN\u00ae 63 Gel Stent who had undergone POAG surgery and had been followed up and controlled between 12 and 36 months.\n Results<\/jats:italic>\n . IOP dropped from 18.02\u2009\u00b1\u20095.23\u2009mmHg preop to 13.81\u2009\u00b1\u20091.88, 14.80\u2009\u00b1\u20092.23, and 14.62\u2009\u00b1\u20091.90 at 1, 2, and 3 years after surgery (\n \n \n p<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n ) consecutively with XEN\u00ae 45 and from 19.00\u2009\u00b1\u20096.11\u2009mmHg preop to 15.47\u2009\u00b1\u20092.45, 14.66\u2009\u00b1\u20092.45, and 15.46\u2009\u00b1\u20092.48 at 1, 2, and 3 years after surgery (\n \n \n p<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:mrow>\n <\/mml:math>\n ) with XEN\u00ae 63. The number of drugs used by patients to treat their glaucoma decreased after undergoing surgery in both groups. Within the XEN\u00ae 45 group, mean changes at 1 year, 2 years, and 3 years amounted to 70%, 74.3%, and 37.5%, respectively, whereas within the XEN\u00ae 63 group, the mean reduction was 75%, 79.8%, and 71.9%. When comparing the outcomes for two groups, the differences did not prove to be statistically significant. More than 90% of the procedures included in the study (using either gel-stent device) were completed without any noteworthy complications.\n Conclusion<\/jats:italic>\n . POAG surgical procedures with either XEN\u00ae 45 or XEN\u00ae 63 Gel Stent implantation could be a safe and effective treatment approach.\n <\/jats:p>","DOI":"10.1155\/2020\/4796548","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T19:31:11Z","timestamp":1584991871000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["Comparing Medium-Term Clinical Outcomes following XEN\u00ae 45 and XEN\u00ae 63 Device Implantation"],"prefix":"10.1155","volume":"2020","author":[{"given":"Aitor","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Miranza IOA Madrid, C\/Galileo 104, Madrid 28003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Miranza IOA Madrid, C\/Galileo 104, Madrid 28003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00eda-Alonso","sequence":"additional","affiliation":[{"name":"Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Andrango","sequence":"additional","affiliation":[{"name":"Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Poyales","sequence":"additional","affiliation":[{"name":"Miranza IOA Madrid, C\/Galileo 104, Madrid 28003, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-0081","authenticated-orcid":true,"given":"Nuria","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Miranza IOA Madrid, C\/Galileo 104, Madrid 28003, Spain"},{"name":"Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705915"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-017-0098-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183142"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0b013e32834ff1e7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-018-0131-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0000000000000336"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16625"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2015.01.019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.01.032"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-019-01232-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.oftale.2015.08.018"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303237"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001045"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0571-x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0310-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13463"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001044"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001360"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119878016"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001364"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2020\/4796548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2020\/4796548.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2020\/4796548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T19:31:12Z","timestamp":1584991872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2020\/4796548\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":22,"alternative-id":["4796548","4796548"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4796548","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]}}}