{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:48:01Z","timestamp":1782604081992,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2020,3,16]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pure red cell aplasia (PRCA) is less common blood disorder; the causes and the treatments of PRCA are varied. <jats:italic>Methods<\/jats:italic>. We conducted a retrospective study during January 2010\u2013December 2017, to explore the etiologies and to evaluate the response and treatment burden in adult patients with PRCA. <jats:italic>Results<\/jats:italic>. Of 32 PRCA patients, median age was 57 years (18\u201390 years). Median hemoglobin level and reticulocyte count at the time of diagnosis were 5.6\u2009g\/dL (3.3\u20137.3\u2009g\/dL) and 0.3% (0.1\u20130.7%), respectively. Median time to hematologic recovery was 12 weeks (3\u201372 weeks), and median number of red blood cell transfusion (RBC) was 20 units (4\u2013100 units). Causes of PRCA were erythropoiesis-stimulating agent (ESA) (47%), parvovirus B19 infection (19%), thymoma (13%), zidovudine (6%), primary autoimmune PRCA (6%), Kaposi\u2019s sarcoma (3%), systemic lupus erythematosus (3%), and ABO-mismatched stem cell transplantation (3%). Only 9 out of 24 treated patients achieved hematologic response within 8 weeks of treatment. Intravenous immunoglobulin therapy provided 100% response rate in patients with parvovirus B19-associated PRCA and primary autoimmune PRCA. Low response rate was found in patients receiving immunosuppressants and chemotherapy for the treatment of ESA and thymoma-associated PRCA, respectively. <jats:italic>Conclusions<\/jats:italic>. Treatment outcome of PRCA depended upon the causes and the types of treatment, and the burden of RBC transfusion was very high in patients with ESA and thymoma-associated PRCA.<\/jats:p>","DOI":"10.1155\/2020\/4812759","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T23:31:51Z","timestamp":1584401511000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-9353","authenticated-orcid":true,"given":"Pimjai","family":"Niparuck","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasana","family":"Kanoksil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathawut","family":"Wacharapornin","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichika","family":"Chantrathammachart","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarinya","family":"Boongird","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-717140"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07216.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa011931"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11655"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050151"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11192"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v128.22.4818.4818"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn450"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0637-1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000629"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06295.x"}],"container-title":["Anemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2020\/4812759.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2020\/4812759.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2020\/4812759.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T23:31:52Z","timestamp":1584401512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/anemia\/2020\/4812759\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":11,"alternative-id":["4812759","4812759"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4812759","relation":{},"ISSN":["2090-1267","2090-1275"],"issn-type":[{"value":"2090-1267","type":"print"},{"value":"2090-1275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]}}}