{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:41Z","timestamp":1791499541279,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012467","name":"Distinguished Professor of Liaoning Province","doi-asserted-by":"publisher","award":["204"],"award-info":[{"award-number":["204"]}],"id":[{"id":"10.13039\/501100012467","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012467","name":"Distinguished Professor of Liaoning Province","doi-asserted-by":"publisher","award":["18-400-4-10"],"award-info":[{"award-number":["18-400-4-10"]}],"id":[{"id":"10.13039\/501100012467","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenyang Science and Technology Innovation \u201cDouble Hundred Project\u201d","award":["204"],"award-info":[{"award-number":["204"]}]},{"name":"Shenyang Science and Technology Innovation \u201cDouble Hundred Project\u201d","award":["18-400-4-10"],"award-info":[{"award-number":["18-400-4-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight\/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters. <jats:italic>Methods<\/jats:italic>. A total of 313 participants were screened from a multicenter prospective prebirth cohort: Born in Shenyang Cohort Study (BISCS). Subjects were examined with a <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>2<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:math> factorial design for body mass index <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mfenced open=\"(\" close=\")\"><mml:mrow><mml:mtext>BMI<\/mml:mtext><\/mml:mrow><\/mml:mfenced><mml:mo>\u2265<\/mml:mo><mml:mn>24<\/mml:mn><\/mml:math> and GDM. Between 24 and 28 weeks of pregnancy, follow-up individuals underwent an OGTT and blood sampling for cardiometabolic characterization. <jats:italic>Results<\/jats:italic>. We observed that the WISP1 levels were elevated in prepregnancy overweight\/obesity patients with GDM, compared with nonoverweight subjects with normal blood glucose (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>3.45<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.89<\/mml:mn><\/mml:math> vs. <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>2.91<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.75<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>ng<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>mL<\/mml:mtext><\/mml:math>). Multilogistic regression analyses after adjustments for potential confounding factors revealed that WISP1 was a strong and independent risk factor for prepregnancy overweight\/obesity with GDM (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>ORs<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:math>). In addition, the results of the ROC analysis indicated that WISP1 exhibited the capability to identify individuals with prepregnancy overweight\/obesity and GDM (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>AUC<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>0.5<\/mml:mn><\/mml:math>). Finally, univariate and multivariate linear regression showed that WISP1 level was positively and independently correlated with fasting blood glucose, systolic blood pressure, and aspartate aminotransferase and was negatively correlated with HDL-C and complement C1q. <jats:italic>Conclusions<\/jats:italic>. WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women.<\/jats:p>","DOI":"10.1155\/2020\/4934206","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T23:36:42Z","timestamp":1586993802000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["Association of WISP1\/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women"],"prefix":"10.1155","volume":"2020","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, China Medical University, Shenyang, Liaoning Province 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajin","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, China Medical University, Shenyang, Liaoning Province 110122, China"},{"name":"Research Center of China Medical University Birth Cohort, China Medical University, Shenyang, Liaoning Province 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenyang Maternity and Child Health Hospital, Shenyang, Liaoning Province 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Dalian Medical University, Dalian, Liaoning Province 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, China Medical University, Shenyang, Liaoning Province 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Public Health, China Medical University, Shenyang, Liaoning 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