{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:19:29Z","timestamp":1791843569269,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":243,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7174358"],"award-info":[{"award-number":["7174358"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800492"],"award-info":[{"award-number":["81800492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection. <jats:italic>Materials and Methods<\/jats:italic>. C57BL\/6J mice were randomly divided into 5 groups: NC (natural control), HP (<jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection), RAC (rabeprazole, amoxicillin, and clarithromycin), RACS (RAC and sucralfate suspension gel), and RACB (RAC and bismuth potassium citrate). HE staining and electron microscopy were performed to estimate histological and ultrastructural damages. The IL\u20108, IL\u201010, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> of gastric antrum tissues were measured by immunohistochemistry and qRT\u2010PCR. ZO\u20101 and Occludin were also detected with immunohistochemistry. The genomes of gastric and fecal microbiota were sequenced. <jats:italic>Results<\/jats:italic>. The eradication rate of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in the RACS group was higher than the RAC group. RACS therapy had protective effects on <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010induced histological and ultrastructural damages, which were superior to the RAC group. RACS therapy reduced the protein and mRNA levels of IL\u20108 compared with the RAC group. The expression of Occludin in the RACS group was significantly higher than that of the RAC group. The composition of gastric and fecal microbiota for RACS was similar to the RACB group according to PCA. <jats:italic>Conclusions<\/jats:italic>. The RACS regimen eradicated <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection effectively and showed RACS had protective effects against <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010induced histological and ultrastructural damage. The mechanisms of RACS effects included decreasing IL\u20108, enhancing Occludin, and transforming gastric microbiota. Moreover, RACS and RACB have a similar effect on gastrointestinal flora.<\/jats:p>","DOI":"10.1155\/2020\/4936318","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T23:30:52Z","timestamp":1598916652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Sucralfate\u2010Combined Quadruple Therapy on Gastric Mucosal Injury Induced by <i>Helicobacter pylori<\/i> and Its Effect on Gastrointestinal Flora"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-4752","authenticated-orcid":false,"given":"Guigen","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-4066","authenticated-orcid":false,"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-7388","authenticated-orcid":false,"given":"Weihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-8111","authenticated-orcid":false,"given":"Huahong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-1167","authenticated-orcid":false,"given":"Fulian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12178"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.09.013"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00788.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12136"},{"key":"e_1_2_9_8_2","first-page":"297","article-title":"Efficacy of compound allantoin containing quadruple regimen in the treatment of chronic gastritis with Helicobacter pylori infection","volume":"34","author":"Cui M. 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