{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:32:21Z","timestamp":1779366741701,"version":"3.53.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comprehensive Investment in Food Hygiene and Nutrition of the Tianjin 13th Five-Year Plan"},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure. <jats:italic>Aim<\/jats:italic>. Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength. <jats:italic>Method<\/jats:italic>. Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases. A total of 18 eligible studies were analyzed in the Reviewer Manager 5.3 software, including 14 English articles and 4 Chinese articles. <jats:italic>Results<\/jats:italic>. In the evaluation of serum vitamin C levels, the concentration in hypertensive subjects is 15.13\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L lower than the normotensive ones (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>mean<\/mml:mtext><mml:mtext>\u2009<\/mml:mtext><mml:mtext>difference<\/mml:mtext><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>15.13<\/mml:mn><\/mml:math>, 95% CI [-24.19, -6.06], and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Serum vitamin C has a significant inverse relation with both systolic blood pressure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>Fishe<\/mml:mtext><mml:msup><mml:mrow><mml:mtext>r<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>\u2019<\/mml:mtext><\/mml:mrow><\/mml:msup><mml:mtext>s<\/mml:mtext><mml:mtext>\u2009<\/mml:mtext><mml:mi>Z<\/mml:mi><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>0.17<\/mml:mn><\/mml:math>, 95% CI [-0.20, -0.15], <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:math>) and diastolic blood pressure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>Fishe<\/mml:mtext><mml:msup><mml:mrow><mml:mtext>r<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>\u2019<\/mml:mtext><\/mml:mrow><\/mml:msup><mml:mtext>s<\/mml:mtext><mml:mtext>\u2009<\/mml:mtext><mml:mi>Z<\/mml:mi><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>0.15<\/mml:mn><\/mml:math>, 95% CI [-0.20, -0.10], <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. People with hypertension have a relatively low serum vitamin C, and vitamin C is inversely associated with both systolic blood pressure and diastolic blood pressure.<\/jats:p>","DOI":"10.1155\/2020\/4940673","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T23:31:05Z","timestamp":1588375865000},"page":"1-11","source":"Crossref","is-referenced-by-count":39,"title":["Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies"],"prefix":"10.1155","volume":"2020","author":[{"given":"Li","family":"Ran","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Suzuka University of Medical Science, Suzuka 510-0293, 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