{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:16Z","timestamp":1787510116297,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670633"],"award-info":[{"award-number":["81670633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974088"],"award-info":[{"award-number":["81974088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFC1314003-1"],"award-info":[{"award-number":["2018YFC1314003-1"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC0906103"],"award-info":[{"award-number":["2016YFC0906103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670633"],"award-info":[{"award-number":["81670633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974088"],"award-info":[{"award-number":["81974088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFC1314003-1"],"award-info":[{"award-number":["2018YFC1314003-1"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC0906103"],"award-info":[{"award-number":["2016YFC0906103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["81670633"],"award-info":[{"award-number":["81670633"]}]},{"name":"National Key R&D Program of China","award":["81974088"],"award-info":[{"award-number":["81974088"]}]},{"name":"National Key R&D Program of China","award":["2018YFC1314003-1"],"award-info":[{"award-number":["2018YFC1314003-1"]}]},{"name":"National Key R&D Program of China","award":["2016YFC0906103"],"award-info":[{"award-number":["2016YFC0906103"]}]},{"name":"National Key R&D Program of China","award":["81670633"],"award-info":[{"award-number":["81670633"]}]},{"name":"National Key R&D Program of China","award":["81974088"],"award-info":[{"award-number":["81974088"]}]},{"name":"National Key R&D Program of China","award":["2018YFC1314003-1"],"award-info":[{"award-number":["2018YFC1314003-1"]}]},{"name":"National Key R&D Program of China","award":["2016YFC0906103"],"award-info":[{"award-number":["2016YFC0906103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics. However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AKI) remains unclear.\n                    <jats:italic>Method<\/jats:italic>\n                    . Medline, Embase, ClinicalTrials.gov, Cochrane Library database, and the China National Knowledge Infrastructure (CNKI) were used to identify relevant studies from their inception to November 31, 2019. Studies that met the inclusion criteria were included. Relevant data were extracted to obtain pooled sensitivity (SEN) and specificity (SPE), summary receiver operating characteristic curve (ROC), and area under the ROC (AUC or AUROC). A bivariate mixed-effects regression model was used for data analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    . A total of 946 patients from 8 eligible studies were included. Across all the studies, the diagnostic odds ratio (DOR) for uKIM-1 level to predict CI-AKI was 19 (95% CI 10\u201339), with SEN and SPE of 0.84 and 0.78, respectively. The AUROC for uKIM-1 in predicting CI-AKI was 0.88 (95% CI 0.85\u20130.90). There was a substantial heterogeneity across the studies (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    was 37.73% for the summary sensitivity and 69.31% for the summary specificity).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Urinary KIM-1 has a high predictive value for diagnosis of CI-AKI in patients who have undergone cardiac catheterization.\n                  <\/jats:p>","DOI":"10.1155\/2020\/4982987","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T19:46:37Z","timestamp":1597434397000},"page":"1-9","source":"Crossref","is-referenced-by-count":18,"title":["The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China"},{"name":"Department of Nephrology, Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Cellular Neurosciences, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Puai Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-2354","authenticated-orcid":true,"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-0546","authenticated-orcid":true,"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2147\/ijnrd.s105124"},{"key":"2","first-page":"85","volume":"4","year":"2011","journal-title":"International Journal of Nephrology and 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