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The current study explored the effect of mmLDL on the endothelin type A (ETA) receptor in mouse mesenteric arteries <jats:italic>in vivo<\/jats:italic>, as well as the role of autophagy in this process. mmLDL was injected via the caudal vein, and the Class III PI3K autophagic pathway inhibitor 3-methyladenine (3-MA) was injected intraperitoneally. The animals were divided into physiological saline (NS), mmLDL, and mmLDL\u2009+\u20093-MA groups. The dose-effect curve of endothelin-1- (ET-1-) induced mesenteric artery contraction was measured using myography, while ET<jats:sub>A<\/jats:sub> receptor mRNA expression was detected using real-time polymerase chain reactions, and the protein levels of the ET<jats:sub>A<\/jats:sub> receptor, class III PI3K, Beclin-1, LC3 II\/I, p62, NF-<jats:italic>\u03ba<\/jats:italic>B, and p-NF-<jats:italic>\u03ba<\/jats:italic>B were observed using Western blot analysis. mmLDL significantly strengthened ET-1-induced contraction (the <jats:italic>E<\/jats:italic><jats:sub>max<\/jats:sub> value increased from 184.87\u2009\u00b1\u20097.46% in the NS group to 319.91\u2009\u00b1\u200920.31% in the mmLDL group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), and the pEC<jats:sub>50<\/jats:sub> value increased from 8.05\u2009\u00b1\u20090.05 to 9.11\u2009\u00b1\u20090.09 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). In addition to upregulating the protein levels of Class III PI3K, Beclin-1, and LC3 II\/I and downregulating that of p62, mmLDL significantly increased the mRNA expression and protein level of the ET<jats:sub>A<\/jats:sub> receptor and increased the protein level of p-NF-<jats:italic>\u03ba<\/jats:italic>B. However, these effects were significantly inhibited by 3-MA. mmLDL activates autophagy via the Class III PI3K\/Beclin-1 pathway and upregulates the ET<jats:sub>A<\/jats:sub> receptor via the downstream NF-<jats:italic>\u03ba<\/jats:italic>B pathway. Understanding the effect of mmLDL on the ET<jats:sub>A<\/jats:sub> receptor and the underlying mechanisms may provide a new idea for the prevention and treatment of cardiovascular diseases.<\/jats:p>","DOI":"10.1155\/2020\/5070436","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T23:31:27Z","timestamp":1585783887000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["The Class III PI3K\/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ET<sub>A<\/sub> Receptor in Mouse Mesenteric Arteries"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xi","family":"Xie","sequence":"first","affiliation":[{"name":"The First People\u2019s Hospital of Chenzhou, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital 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