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Most of the AD cases are late onset, and the apolipoprotein E (<jats:italic>APOE<\/jats:italic>) isoform is a key genetic risk factor. The<jats:italic>APOE<\/jats:italic>gene has 3 key alleles in humans including<jats:italic>APOE2<\/jats:italic>,<jats:italic>APOE3<\/jats:italic>, and<jats:italic>APOE4<\/jats:italic>. Among them,<jats:italic>APOE4<\/jats:italic>is the most potent genetic risk factor for late-onset AD (LOAD), while<jats:italic>APOE2<\/jats:italic>has a defensive effect. Research data suggest that<jats:italic>APOE4<\/jats:italic>leads to the pathogenesis of AD through various processes such as accelerated beta-amyloid aggregations that raised neurofibrillary tangle formation, cerebrovascular diseases, aggravated neuroinflammation, and synaptic loss. However, the precise mode of actions regarding in what way<jats:italic>APOE4<\/jats:italic>leads to AD pathology remains unclear. Since<jats:italic>APOE<\/jats:italic>contributes to several pathological pathways of AD, targeting<jats:italic>APOE4<\/jats:italic>might serve as a promising strategy for the development of novel drugs to combat AD. In this review, we focus on the recent studies about<jats:italic>APOE4<\/jats:italic>-targeted therapeutic strategies that have been advanced in animal models and are being prepared for use in humans for the management of AD.<\/jats:p>","DOI":"10.1155\/2020\/5086250","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:28:46Z","timestamp":1589588926000},"page":"1-16","source":"Crossref","is-referenced-by-count":48,"title":["Molecular Insight into the Therapeutic Promise of Targeting<i>APOE4<\/i>for Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-5616","authenticated-orcid":true,"given":"Abdullah Al","family":"Mamun","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Southeast University, Dhaka, Bangladesh"},{"name":"Pharmakon Neuroscience Research Network, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-7840","authenticated-orcid":true,"given":"Md. 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