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Thirty Wistar rats were divided into three groups (varicocele\/sham\/control) and analyzed two months after the induction of varicocele. Testicular tissue sections and epididymal mature sperm were then monitored for classic features of varicocele, including disturbance of spermatogenesis, impaired testicular carbohydrate and lipid homeostasis, decreased sperm count, increased sperm nuclear immaturity and DNA damage, oxidative stress, and lipid peroxidation. At the same time, we evaluated the Atg7 protein content and LC3-II\/LC3-1 protein ratio in testis and mature sperm cells, two typical markers of early and late cellular autophagy, respectively. We report here that testis and mature sperm show higher signs of autophagy in the varicocele group than in the control and sham groups, probably to try to mitigate the consequences of VCL on the testis and germ cells.<\/jats:p>","DOI":"10.1155\/2020\/5140383","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T23:31:30Z","timestamp":1586820690000},"page":"1-11","source":"Crossref","is-referenced-by-count":40,"title":["Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4388-4566","authenticated-orcid":true,"given":"Niloofar","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"},{"name":"Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Erfani-Majd","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran"},{"name":"Stem Cells and Transgenic Technology Research Center, Shahid Chamran University of Ahvaz, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziyeh","family":"Tavalaee","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Tabandeh","sequence":"additional","affiliation":[{"name":"Stem Cells and Transgenic Technology Research Center, Shahid Chamran University of Ahvaz, Ahvaz, Iran"},{"name":"Department of Basic Sciences, Division of Biochemistry and Molecular Biology, Faculty of 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