{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:14:34Z","timestamp":1779120874204,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital Clinical Characteristic Application Research Project","award":["Z181100001718195"],"award-info":[{"award-number":["Z181100001718195"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The mammalian orosomucoid\u2010like gene family (<jats:italic>ORMDL<\/jats:italic>), containing <jats:italic>ORMDL1<\/jats:italic>, <jats:italic>ORMDL2<\/jats:italic>, and <jats:italic>ORMDL3<\/jats:italic>, is the important regulator of sphingolipid metabolism, which is relevant to cell growth, proliferation, migration, and invasion. Since the role of <jats:italic>ORMDL1<\/jats:italic> in cancers remained unclear, the main purpose of our study was to explore the expression patterns and prognostic values of <jats:italic>ORMDL1<\/jats:italic> in different tumors, especially in cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM). Bioinformatics tools including GEPIA, CCLE, LinkedOmics, cBioPortal, and TIMER databases were used. As a result, the expression levels of <jats:italic>ORMDL1<\/jats:italic> in tumor tissues and normal tissues varied in different cancers, especially significantly upregulated in CHOL, DLBCL, LAML, and THYM. Moreover, <jats:italic>ORMDL1<\/jats:italic> mRNA was also highly expressed in cell lines of DLBCL and LAML. Further studies showed that <jats:italic>ORMDL1<\/jats:italic> overexpression was associated with poor prognosis in DLBCL, but not significant in CHOL, LAML, and THYM. Consistently, there were genetic alterations of <jats:italic>ORMDL1<\/jats:italic> in DLBCL, and patients with genetic alterations indicated worse survival. Coexpressed genes and related biological events with <jats:italic>ORMDL1<\/jats:italic> in DLBCL were found via LinkedOmics, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The relationship between <jats:italic>ORMDL1<\/jats:italic> and cancer immune cells was investigated, and <jats:italic>ORMDL1<\/jats:italic> expression was positively correlated with infiltrating levels of B cells. In conclusion, <jats:italic>ORMDL<\/jats:italic>1 is suggested to be a tumorigenic factor and considered as the potential therapeutic target and prognostic biomarker in DLBCL.<\/jats:p>","DOI":"10.1155\/2020\/5178397","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T02:35:09Z","timestamp":1603334109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Expression Patterns and Prognostic Values of ORMDL1 in Different 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