{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:56:25Z","timestamp":1753887385852,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":147,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis. Genetic factors are associated with the occurrence of OA. While several studies have shown that the matrix metalloproteinase\u20101\u2010 (MMP\u20101\u2010) 1607 1G\/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature. To better estimate the relationship between the MMP\u20101 gene polymorphism and OA, a comprehensive meta\u2010analysis of relevant literature was carried out. <jats:italic>Results<\/jats:italic>. In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta\u2010analysis. The combined results revealed no significant association between the MMP\u20101\u20101607 1G\/2G polymorphism and risk of OA in the five genetic models. However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP\u20101\u20101607 1G\/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs. 1G: OR = 1.575, 95<jats:italic>%<\/jats:italic>CI = 1.259\u20131.972, <jats:italic>P<\/jats:italic> &lt; 0.01; recessive: 2G2G vs. 1G1G+1G2G: OR = 2.411, 95<jats:italic>%<\/jats:italic>CI = 1.658\u20133.504, <jats:italic>P<\/jats:italic> &lt; 0.01; and homozygote: 2G2G vs. 1G1G: OR = 2.313, 95<jats:italic>%<\/jats:italic>CI = 1.341, 3.991, <jats:italic>P<\/jats:italic> = 0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs. 1G: OR = 1.635, 95<jats:italic>%<\/jats:italic>CI = 1.354, 1.974, <jats:italic>P<\/jats:italic> &lt; 0.01; dominant: 2G1G+2G2G vs. 1G1G: OR = 1.622, 95<jats:italic>%<\/jats:italic>CI = 1.158, 2.271, <jats:italic>P<\/jats:italic> = 0.005; recessive: 2G2G vs. 1G1G+1G2G: OR = 2.209, 95<jats:italic>%<\/jats:italic>CI = 1.718, 2.840, <jats:italic>P<\/jats:italic> &lt; 0.01; and homozygote: 2G2G vs. 1G1G: OR = 2.578, 95<jats:italic>%<\/jats:italic>CI = 1.798, 3.696, <jats:italic>P<\/jats:italic> &lt; 0.01), the larger subgroup (<jats:italic>N<\/jats:italic> &gt; 300), and the hospital\u2010based case\u2010control study (HCC) subgroup. The sensitivity analysis suggested that the results of the meta\u2010analysis were stable and reliable. Begg\u2019s funnel plot and Egger\u2019s test indicated that there was no publication bias in this study. <jats:italic>Conclusion<\/jats:italic>. Our meta\u2010analysis indicated that although the MMP\u20101\u20101607 1G\/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.<\/jats:p>","DOI":"10.1155\/2020\/5190587","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T23:38:04Z","timestamp":1590622684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between the MMP\u20101\u20101607 1G\/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jiankun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-4285","authenticated-orcid":false,"given":"Zhan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27184"},{"key":"e_1_2_8_2_2","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf A. 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