{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:35:52Z","timestamp":1782484552469,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2313-B-032-001"],"award-info":[{"award-number":["MOST 109-2313-B-032-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Zhibai Dihuang Wan (ZDW) is an eight\u2010herbal formula of traditional Chinese medicine. Clinically, it regulated immune activity and was used to treat diabetes and renal disease. In this study, we aimed to explore the nephroprotective effect of ZDW in an aristolochic acid\u2010 (AA\u2010) intoxicated zebrafish model. We used a green fluorescent kidney transgenic zebrafish to evaluate the nephroprotective effects of ZDW by recording subtle changes in the kidney. Our results demonstrated that ZDW treatment can attenuate AA\u2010induced kidney malformations (60% for AA\u2010treated, 47% for pretreatment with ZDW, and 17% for cotreatment ZDW with AA, <jats:italic>n<\/jats:italic> = 50). Furthermore, we found that the expression levels of <jats:italic>tnf\u03b1<\/jats:italic> and <jats:italic>mpo<\/jats:italic> were decreased either in pretreatment or cotreatment groups. In conclusion, our findings revealed that AA\u2010induced nephrotoxicities can be attenuated by ZDW. Therefore, we believe that zebrafish represent an efficient model for screening AA\u2010protective Chinese medicine.<\/jats:p>","DOI":"10.1155\/2020\/5204348","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T02:14:57Z","timestamp":1606961697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid\u2010Intoxicated Zebrafish"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-6811","authenticated-orcid":false,"given":"Ping-Hsun","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun-Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Liang","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Fen","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Li","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-7464","authenticated-orcid":false,"given":"Yau-Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"24","article-title":"Clinical study on Zhibai Dihuang decoction combined with endocrine therapy in treating kidney-yin deficiency type of advanced prostate cancer","volume":"23","author":"Liu H.","year":"2016","journal-title":"Chinese Journal of Information on Traditional Chinese Medicine"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.001"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00376"},{"key":"e_1_2_8_4_2","article-title":"Clinical observation on curative effect of 85 patients with chronic renal insufficiency","volume":"6","author":"Huaiwen X.","year":"1995","journal-title":"Journal of Zhejiang College of Tcm"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9294605"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.031"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-017-0160-y"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.11.031"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050537"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7010097"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv125"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006200"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2019.02.005"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.06.022"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.23.4655"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(03)00124-7"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.03.011"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm235"},{"key":"e_1_2_8_20_2","article-title":"Anti-inflammatory activities of compounds isolated from the rhizome of Anemarrhena asphodeloides","volume":"23","author":"Wang Z.","year":"2018","journal-title":"Molecules"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.013"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01336.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-018-0191-z"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.01.029"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-101"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)01063-7"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2316"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.04.160"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.4149"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9680"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.895"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2016.1239867"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.03.107"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6142"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/5204348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/5204348.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/5204348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:33:25Z","timestamp":1735630405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/5204348"}},"subtitle":[],"editor":[{"given":"Elena","family":"Baralla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/5204348"],"URL":"https:\/\/doi.org\/10.1155\/2020\/5204348","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5204348"}}