{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:37:03Z","timestamp":1777441023047,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/6-164-01\/503-66-001"],"award-info":[{"award-number":["503\/6-164-01\/503-66-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/6-164-01\/503-61-001"],"award-info":[{"award-number":["503\/6-164-01\/503-61-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Mast cells (MCs) are engaged in the processes of host defense, primarily\n                    <jats:italic>via<\/jats:italic>\n                    the presence of receptors responsible for the detection of pathogen\u2010associated molecular patterns (PAMPs). Since BDs are exclusively host defense molecules, and MCs can elicit the antimicrobial response, this study is aimed at determining whether BDs might be involved in MC pathogen defense. We found that defensin BD\u20102 significantly augments the mRNA and protein expression of Toll\n                    <jats:italic>-<\/jats:italic>\n                    like receptors (TLRs) and retinoic acid\u2010inducible gene\u2010I\u2010like receptor (RLR) essential for the detection of viral molecules, i.e., TLR3, TLR7, TLR9, and RIG\u2010I in mature tissue rat peritoneal MCs (PMCs). We established that BD\u20102 might stimulate PMCs to release proinflammatory and immunoregulatory mediators and to induce a migratory response. Presented data on IgE\u2010coated PMC upon BD\u20102 treatment suggest that in the case of allergies, there is an enhanced MC immune response and cell influx to the site of the ongoing infection. In conclusion, our data highlight that BD\u20102 might strongly influence MC features and activity, mainly by strengthening their role in the inflammatory mechanisms and controlling the activity of cells participating in antimicrobial processes.\n                  <\/jats:p>","DOI":"10.1155\/2020\/5230172","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T19:34:33Z","timestamp":1588016073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>\u03b2<\/i>\n                    \u2010Defensin Strengthens Antimicrobial Peritoneal Mast Cell Response"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-5737","authenticated-orcid":false,"given":"Justyna","family":"Agier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-4321","authenticated-orcid":false,"given":"Ewa","family":"Brzezi\u0144ska-B\u0142aszczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"R\u00f3\u017calska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Wiktorska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1834-4739","authenticated-orcid":false,"given":"Sebastian","family":"Wawrocki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6626-3215","authenticated-orcid":false,"given":"Paulina","family":"\u017belechowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.09.018"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.017"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000336619"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5540-2"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.07.004"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00294"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.007"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414545334"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.08.002"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00569"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12634"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9533-9_10"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12670"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2017.71526"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.12.014"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174241"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12623"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-018-1164-5"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2009.00174.x"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1205357"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2016.65141"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2015.51359"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277152"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.03.001"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803587"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200104)31:4<1066::AID-IMMU1066>3.0.CO;2-#"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900712"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.12.006"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7357162"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxu069"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636379"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000136"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.212"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30289-w"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.425"},{"key":"e_1_2_11_37_2","first-page":"4051","article-title":"Elevated serum \u03b2-defensins concentrations in patients with lung cancer","volume":"24","author":"Arimura Y.","year":"2004","journal-title":"Anticancer Research"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.081430"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004725"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/5230172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/5230172.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/5230172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:15:23Z","timestamp":1762092923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/5230172"}},"subtitle":[],"editor":[{"given":"Bogdan","family":"Kolarz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/5230172"],"URL":"https:\/\/doi.org\/10.1155\/2020\/5230172","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5230172"}}