{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:37:48Z","timestamp":1781566668472,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010881","name":"Suzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["SYS201764"],"award-info":[{"award-number":["SYS201764"]}],"id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,3,3]]},"abstract":"<jats:p><jats:italic>Aim.<\/jats:italic> Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically evaluate the diagnostic value of HSF in predicting BA. <jats:italic>Methods.<\/jats:italic> A comprehensive literature search of four databases was conducted to identify the eligible studies. All analyses were performed using STATA 12.0. <jats:italic>Results.<\/jats:italic> Nine studies from eight articles containing 368 patients and 469 controls were included in our meta-analysis. Briefly, the values for pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.95 (95% CI 0.88-0.98), 0.92 (95% CI 0.85-0.96), 11.6 (95% CI 6.3-21.5), 0.06 (95% CI 0.02-0.14), 201 (95% CI 59-689), and 0.98 (95% CI 0.96-0.99), respectively. Additionally, metaregression along with subgroup analysis based on various covariates revealed the potential sources of heterogeneity and the detailed diagnostic value in each subgroup. <jats:italic>Conclusion.<\/jats:italic> Our meta-analysis showed that HSF assay could provide high accuracy in predicting BA patients and non-BA individuals. However, further studies with better design and larger sample size are required to support the results of the present study.<\/jats:p>","DOI":"10.1155\/2020\/5262565","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T18:30:57Z","timestamp":1583260257000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-0130","authenticated-orcid":true,"given":"Chao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of General Surgery, Soochow University Affiliated Children\u2019s Hospital, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Soochow University Affiliated Children\u2019s Hospital, Suzhou, 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