{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:42:33Z","timestamp":1783525353904,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":292,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013844","name":"Fundaci\u00f3n Mundo Sano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005872","name":"Bahir Dar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. <jats:italic>Schistosoma mansoni<\/jats:italic> is a parasitic worm that infects humans throughout the world. It is more prevalent in sub\u2010Saharan Africa including Ethiopia. Proper detection of <jats:italic>Schistosoma mansoni<\/jats:italic> using sensitive diagnostic methods is crucial in the prevention and control era. Since direct wet mount microscopy with its low sensitivity has been used as a diagnostic technique in Ethiopia, searching alternative diagnostic methods which have better sensitivity should be a priority agenda. <jats:italic>Objective<\/jats:italic>. This study is aimed at evaluating the performance of diagnostic methods for <jats:italic>Schistosoma mansoni<\/jats:italic> in Amhara region. <jats:italic>Methods<\/jats:italic>. A cross\u2010sectional study was conducted among 520 school children from October to December 2019 in Amhara region. The study participants were selected by a systematic random sampling technique. Stool samples were collected from each participant and processed via formol\u2010ether concentration, Kato\u2010Katz, and spontaneous tube sedimentation techniques. The data was entered into EpiData version 3.1, and analysis was done using SPSS version 20. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated against the combined result as \u201cGold\u201d standard. A kappa value was computed to measure the strength of agreement of the diagnostic methods. <jats:italic>Results<\/jats:italic>. The overall prevalence of <jats:italic>Schistosoma mansoni<\/jats:italic> was 20.2% using a combination of three methods. The prevalence of 8.3%, 12.9%, and16.3%, respectively, was recorded by using formol\u2010ether concentration, Kato\u2010Katz, and spontaneous tube sedimentation. The spontaneous tube sedimentation method (81.0%) had better sensitivity compared to Kato\u2010Katz (63.8%) and formol\u2010ether concentration (41.0%) methods in <jats:italic>Schistosoma mansoni<\/jats:italic> detection. <jats:italic>Conclusion<\/jats:italic>. The spontaneous tube sedimentation technique is more sensitive and has better detection rate to <jats:italic>Schistosoma mansoni<\/jats:italic> infection followed by the Kato\u2010Katz technique. Therefore, updating the current diagnostic methods for <jats:italic>Schistosoma mansoni<\/jats:italic> could be a priority agenda to take action in schistosomiasis prevention and control.<\/jats:p>","DOI":"10.1155\/2020\/5312512","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T02:50:12Z","timestamp":1603162212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Performance Evaluation of Diagnostic Methods for <i>Schistosoma mansoni<\/i> Detection in Amhara Region, Northwest Ethiopia"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-5639","authenticated-orcid":false,"given":"Abebe","family":"Fenta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadesse","family":"Hailu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megbaru","family":"Alemu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arancha","family":"Amor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"crossref","unstructured":"Infectious Disease Clinics of North America 2012 26 Gryseels: Schistosomiasis","DOI":"10.1016\/j.idc.2012.03.004"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_2_11_3_2","volume-title":"Second Edition of Ethiopia National Master Plan for Neglected Tropical Diseases","author":"Health FDRoEMo","year":"2016"},{"key":"e_1_2_11_4_2","first-page":"75","article-title":"Ethiopia schistosomiasis and soil-transmitted Helminthes control programme: progress and prospects","volume":"55","author":"Negussu N.","year":"2017","journal-title":"Ethiopian Medical Journal"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-3008-0"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.2.263"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/792536"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1742395307084407"},{"key":"e_1_2_11_10_2","first-page":"305","article-title":"Spontaneous sedimentation in tube technique (SSTT) for diagnosis of intestinal parasites","volume":"29","author":"Terashima A.","year":"2009","journal-title":"Revista de gastroenterolog\u00eda del Per\u00fa: \u00f3rgano oficial de la Sociedad de Gastroenterolog\u00eda del Per\u00fa"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.12.017"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13727"},{"key":"e_1_2_11_13_2","volume-title":"Prevention and Control of Schistosomiasis and Soil-Transmitted Helminthiasis, Technical Report Series","author":"WHO","year":"2002"},{"key":"e_1_2_11_14_2","volume-title":"Increasing Access to Diagnostics through Technology Transfer and Local Production","author":"WHO","year":"2011"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2011.11.006"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2011.06.020"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.11.013"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.09.009"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.09.003"},{"key":"e_1_2_11_20_2","unstructured":"ANRSEFD Amhara National Regional State economic and finance development office report 2017 https:\/\/www.amharabofed.gov.et\/population_report.html."},{"key":"e_1_2_11_21_2","article-title":"An ether sedimentation technique for routine stool examinations","volume":"8","author":"Ritchie L. S.","year":"1948","journal-title":"Bulletin of the United States Army medical department"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2004.00183.x"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529786"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2019-1"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.11648\/j.ajhr.20140205.18"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201100059X"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000900009"},{"key":"e_1_2_11_28_2","first-page":"1","article-title":"Survey of schistosomiasis and other intestinal helminthiases among school-aged children in Agaie, Niger state Nigeria","volume":"15","author":"Banji B.","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Sciences"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.11648\/j.jfmhc.20160204.16"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3971-x"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181547"},{"key":"e_1_2_11_32_2","first-page":"25","article-title":"Prevalence of intestinal parasites and associated risk factors among students of Atse Fasil general elementary school Azezo, Northwestern Ethiopia","volume":"3","author":"Endris M.","year":"2010","journal-title":"Ethiopian Journal of Health Sciences"},{"key":"e_1_2_11_33_2","volume-title":"IOP Conference Series: Earth and Environmental Science","author":"Fitriani C.","year":"2018"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.5402\/2013\/180439"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1822-4"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000754"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0049475515581127"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/5312512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/5312512.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/5312512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T09:38:50Z","timestamp":1735637930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/5312512"}},"subtitle":[],"editor":[{"given":"Adriano","family":"Casulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/5312512"],"URL":"https:\/\/doi.org\/10.1155\/2020\/5312512","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5312512"}}