{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:42:13Z","timestamp":1777416133311,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":356,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874345"],"award-info":[{"award-number":["81874345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020-MS-223"],"award-info":[{"award-number":["2020-MS-223"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The desert\u2010dwelling <jats:italic>Cistanche<\/jats:italic> herb was first recorded in the \u201cShen Nong Herbal Classic\u201d and is listed as the top\u2010grade herbal medicine in this publication. The Chinese Pharmacopoeia records that pieces of <jats:italic>Cistanche deserticola<\/jats:italic> (CD) and rice wine\u2010steamed <jats:italic>Cistanche deserticola<\/jats:italic> (WCD) can be used in the clinic as the main types of decoctions. After being steamed with rice wine, the antiaging and tonifying kidney\u2010yang effects are enhanced. In this study, we detected the chemical content of CD and WCD and the pharmacological mechanism of invigorating kidney\u2010yang deficiency in model rats. <jats:italic>Aim<\/jats:italic>. The purpose of this study was to examine the effects of CD and WCD on the neuroendocrine\u2010immune function of kidney\u2010yang deficiency in glucocorticoid\u2010overdosed model rats. <jats:italic>Materials and methods<\/jats:italic>. Sprague Dawley (SD) rats were selected. The rats were subcutaneously injected with corticosterone water suspension for the glucocorticoid\u2010overdosed model rats. The positive control rats were gavaged with Jinkuishenqi pills and high\u2010, medium\u2010, and low\u2010dose CD\/WCD suspensions (1.646\u2009g\/(kg day), 5.48\u2009g\/(kg day), 2.74\u2009g\/(kg day), and 1.37\u2009g\/(kg day), respectively); the blank control (BC) and model control (MC) groups were given the same volume of distilled water as those in the drug group for 40 consecutive days at a dose of 1\u2009mL\/100\u2009g. After the last administration, the blood was collected from the abdominal aorta, and serum levels of T, CRH, ACTH, CORT, cortisol, IL\u201010, IL\u20106, IL\u20102, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IFN\u2010<jats:italic>\u03b3<\/jats:italic> were measured. Organ indexes of the thymus gland and the spleen were calculated. The expression of Bax, Bcl\u20102, caspase\u20103, Fas, and FasL in the adrenal gland was measured by immunohistochemistry. The pathological changes in the thymus gland and the adrenal gland were observed by HE staining (\u00d7200). T lymphocyte subsets in peripheral blood were detected by flow cytometry, and the expression of CaM mRNA in the hypothalamus and hypophysis tissues was also measured by RT\u2010PCR. <jats:italic>Results<\/jats:italic>. Compared with the MC group, the CD and WCD groups exhibited increases in activity, the organ index of the thymus and the spleen, the serum levels of T, CRH, ACTH, CORT, cortisol, IL\u20102, and IL\u201010, the ratio of CD4+\/CD8+, and the expression of Bcl\u20102, caspase\u20103, Fas, FasL, and CaM in the hypophysis tissue. The CD and WCD groups also exhibited reductions in the IL\u20106, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IFN\u2010<jats:italic>\u03b3<\/jats:italic> levels in serum and the expression of CaM mRNA in the hypothalamus. <jats:italic>Conclusions<\/jats:italic>. Each dose of CD and WCD could counteract the dysregulated sex hormone and immune factors in glucocorticoid\u2010overdosed model rats, enhancing and restoring the effect of the hypothalamic nerve cells and improving immune function.<\/jats:p>","DOI":"10.1155\/2020\/5321976","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:20:10Z","timestamp":1608661210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Study on Neuroendocrine\u2010Immune Function of <i>Cistanche deserticola<\/i> and Its Rice Wine Steaming Products in Glucocorticoid\u2010Induced Rat Model"],"prefix":"10.1155","volume":"2020","author":[{"given":"Bonan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-4662","authenticated-orcid":false,"given":"Ji","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-0859","authenticated-orcid":false,"given":"Wei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"169","article-title":"Comparison on the kidney nourishing and yang strengthening functions of three different species of Herba Cistanches","volume":"19","author":"Zhang Y.","year":"1994","journal-title":"China J Chin Mater Med"},{"key":"e_1_2_8_2_2","volume-title":"Pharmacopoeia of People\u2019s Republic of China:One Edition","author":"Chinese Pharmacopoeia Commission","year":"2015"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12103"},{"key":"e_1_2_8_4_2","first-page":"364","article-title":"Glycosides of Cistanche anti-lipid peroxidation and anti-radiation effect","volume":"22","author":"Li L. 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