{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:35:27Z","timestamp":1784903727754,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pelvic inflammatory disease (PID) without timely and proper treatment can cause long\u2010term sequelae; meanwhile, patients will be confronted with the antimicrobial resistance and side effects. Chinese patent medicine as a supplement is used to treat PID with satisfactory clinical efficacy. This study evaluated the efficacy and safety of Fuke Qianjin (FKQJ) combined with antibiotics in the treatment of PID. <jats:italic>Methods<\/jats:italic>. Eight electronic databases and other resources were searched to make a collection of the randomized controlled trials (RCTs) from 1990 to 2019. The RCTs contrasting the effect of FKQJ combined with antibiotics regimens and antibiotics alone in reproductive women with PID were included. The antibiotics regimens are all recommended by the guidelines. Two reviewers independently screened the studies, extracted the data, and assessed the methodological quality of the included studies. Then, the meta\u2010analyses were performed by RevMan 5. 3 software if appropriate. <jats:italic>Results<\/jats:italic>. Twenty\u2010three RCTs (2527 women) were included in this review. The evidence showed that FKQJ combined with antibiotics improved the markedly effective rate compared to antibiotics alone group (RR\u2009=\u20091.38, 95% CI 1.27 to 1.49, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200942%), shortened the improvement time of low abdominal pain (MD\u2009=\u2009\u22121.11, 95% CI \u22121.39 to \u22120.84, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200938%), and increased the rate of lower abdominal pain improvement (RR\u2009=\u20091.35, 95% CI 1.19 to 1.55, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090). The implementation of adjuvant reduced the recurrent rate compared with antibiotics alone (RR\u2009=\u20090.27, 95% CI 0.13 to 0.56, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). <jats:italic>Conclusions<\/jats:italic>. Based on available evidence, FKQJ combined with antibiotics therapy have certain outcomes on increasing the markedly effective rate, decreasing the recurrent rate compared with antibiotics alone group. This therapy appears to improve lower abdominal pain and curtail the relief time. Due to the low quality and the risk of bias, any high\u2010quality evidence or longer follow\u2010up period should be advisable and necessary in the future.<\/jats:p>","DOI":"10.1155\/2020\/5372839","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T23:34:44Z","timestamp":1595374484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fuke Qianjin Combined with Antibiotic Therapy for Pelvic Inflammatory Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-7397","authenticated-orcid":false,"given":"Shaobin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caimmiao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000154508.26532.6a"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000162361.69041.a5"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e364"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1361822"},{"key":"e_1_2_11_5_2","first-page":"721","article-title":"Epidemiology of pelvic inflammatory diseases","volume":"29","author":"Wu W. X.","year":"2013","journal-title":"Journal of Practical Obstetrics and Gynecology"},{"key":"e_1_2_11_6_2","first-page":"469","article-title":"Diagnosis, treatment and research status of female reproductive tract infection in China","volume":"38","author":"Liao Q. P.","year":"2011","journal-title":"Journal of International Obstetrics and Gynecology"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000175375.60973.cb"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1538"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181f22f3e"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ771"},{"key":"e_1_2_11_11_2","first-page":"98","article-title":"Observation on the efficacy of Kangfu Xiaoyan suppository combined with antibiotics in the treatment of pelvic inflammation","volume":"6","author":"Wei R. F.","year":"2017","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-007-9119-x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.03.004"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1466-5"},{"key":"e_1_2_11_15_2","unstructured":"HigginsJ. P. T.andGreenS. Cochrane handbook for systematic reviews of interventions version 5.1.0 2011 The Cochrane Collaboration London UK."},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_11_17_2","first-page":"33","article-title":"Influence of fuke Qianjin tablets on expression of serum inflammatory mediator in patients with acute pelvic inflammation","volume":"23","author":"Li J.","year":"2014","journal-title":"China Pharmaceuticals"},{"key":"e_1_2_11_18_2","first-page":"88","article-title":"Effect of antibiotic combined with gynecologic Qian Jin tablets in the treatment of endometritis","volume":"34","author":"Zhang H. H.","year":"2018","journal-title":"Chinese Community Doctors"},{"key":"e_1_2_11_19_2","first-page":"5000","article-title":"Clinical effect of antibiotics and gynecological Qianjin tablets in the treatment of endometritis","volume":"12","author":"Du F. Y.","year":"2017","journal-title":"Public Medical Forum Magazine"},{"key":"e_1_2_11_20_2","first-page":"89","article-title":"Therapeutic effect of antibiotics combined with gynecological Qianjin tablets on endometritis","volume":"6","author":"Meng Y. J.","year":"2018","journal-title":"Psychologies"},{"key":"e_1_2_11_21_2","article-title":"Clinical observation of antibiotics combined with gynecological Qianjin tablets in the treatment of endometritis","volume":"8","author":"Chang J. H.","year":"2016","journal-title":"Journal of Chinese Baby"},{"key":"e_1_2_11_22_2","first-page":"3040","article-title":"Clinical effect of antibiotics combined with gynecological Qianjin tablet in the treatment of endometritis","volume":"8","author":"Fan C. F.","year":"2016","journal-title":"Maternal and Child Health Care of China"},{"key":"e_1_2_11_23_2","first-page":"141","article-title":"Clinical effect of metronidazole, medroxyprogesterone and gynecological Qianjin tablets in the treatment of endometritis","volume":"11","author":"Liu X. Z.","year":"2017","journal-title":"The World Clinical Medicine"},{"key":"e_1_2_11_24_2","first-page":"291","article-title":"Clinical effect of antibiotics combined with gynecological Qianjin tablet in the treatment of endometritis","volume":"39","author":"Guo Y.","year":"2015","journal-title":"Journal of Heilongjiang Medical"},{"key":"e_1_2_11_25_2","first-page":"61","article-title":"Application and efficacy analysis of Qianjin capsule plus antibiotics in the treatment of endometritis","volume":"1","author":"Shen J. Q.","year":"2018","journal-title":"Medical Diet and Health"},{"key":"e_1_2_11_26_2","first-page":"21","article-title":"Clinical efficacy of antibacterial agents combined with fuke Qianjin tablets in treating endometritis","volume":"11","author":"Wang C. X.","year":"2018","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"key":"e_1_2_11_27_2","first-page":"178","article-title":"Clinical effect of gynecological Qianjin tablet on endometritis","volume":"14","author":"Lou S. Q.","year":"2017","journal-title":"Journal of North Pharmacy"},{"key":"e_1_2_11_28_2","first-page":"82","article-title":"Clinical effects of antibiotics combined with gynecologic Qianjin tablets on endometritis","volume":"29","author":"Chen X. H.","year":"2017","journal-title":"Medical Journal of Chinese People\u2019s Health"},{"key":"e_1_2_11_29_2","article-title":"Observation on the effect of Qianjin tablet combined with metronidazole in the treatment of dndometritis","volume":"22","author":"Liu W. P.","year":"2019","journal-title":"Science Regimen"},{"key":"e_1_2_11_30_2","first-page":"22","article-title":"Observation on the effect of antibiotics combined with fukeqianjin tablet in the treatment of 80 cases of endometritis","volume":"25","author":"Zheng Q.","year":"2019","journal-title":"Health Guide"},{"key":"e_1_2_11_31_2","first-page":"104","article-title":"Clinical effect of antibiotic combined with hormone and fukeqianjin tablet in the treatment of endometritis","volume":"32","author":"Lin B. Y.","year":"2019","journal-title":"Medical Equipment"},{"key":"e_1_2_11_32_2","first-page":"176","article-title":"Analysis of the effect of Gynecology Qianjin tablet combined with metronidazole in the treatment of endometritis","volume":"17","author":"Zhang L.","year":"2019","journal-title":"Contemporary Medical Symposium"},{"key":"e_1_2_11_33_2","first-page":"275","article-title":"Observation on the efficacy of antibiotics combined with gynecological Qianjin capsule in the treatment of acute endometritis","volume":"3","author":"Zhang P.","year":"2017","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"key":"e_1_2_11_34_2","first-page":"417","article-title":"Clinical efficacy of combination of gynecological Qianjin tablet and clindamycin phosphate in the treatment of endometritis","volume":"12","author":"Yuan B.","year":"2015","journal-title":"Anti-Infection Pharmacy"},{"key":"e_1_2_11_35_2","first-page":"89","article-title":"Application of Fukeqianjin capsule in the treatment of pelvic inflammatory diseases","volume":"6","author":"Chen L.","year":"2019","journal-title":"Women\u2019s Health Research"},{"key":"e_1_2_11_36_2","first-page":"3330","article-title":"Therapeutic effect of antibiotics combined with gynecological Qianjin soft capsule on pelvic inflammation","volume":"19","author":"Yuan Y.","year":"2012","journal-title":"The Medical Forum"},{"key":"e_1_2_11_37_2","first-page":"72","article-title":"Clinical study of 60 cases of endometritis treated with levofloxacin combined with fuke Qianjin tablets","volume":"2","author":"He H. F.","year":"2017","journal-title":"Clinical Research and Practice"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6545-4"},{"key":"e_1_2_11_39_2","first-page":"94","article-title":"Observation on the clinical effect of antibiotic combined with Gynecology Qianjin tablet in the treatment of endometritis","volume":"12","author":"Deng Y. Y.","year":"2019","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"key":"e_1_2_11_40_2","first-page":"3091","article-title":"Meta-analysis on efficacy of fuke Qianjin tablets (capsules) combined with antibiotics in treatment of endometritis","volume":"41","author":"Wang L.","year":"2016","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_11_41_2","first-page":"401","article-title":"Gynecology and obstetrics branch, Chinese medical association, \u201cguideline for diagnosis and treatment of pelvic inflammatory diseases (revised edition)","volume":"49","author":"Collaborative Group on Infectious Diseases","year":"2014","journal-title":"Chinese Journal of Obstetrics and Gynecology"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-018-0217-6"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/5372839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/5372839.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/5372839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:44:46Z","timestamp":1723020286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/5372839"}},"subtitle":[],"editor":[{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/5372839"],"URL":"https:\/\/doi.org\/10.1155\/2020\/5372839","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5372839"}}