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It is often used as an ornamental shrub due to its golden leaves. However, its medical value is yet to be discovered. Recently, plant polysaccharides have attracted comprehensive attention owing to their biological properties, including immunomodulatory and antioxidant activities. This study aimed to extract, purify, and characterize the polysaccharide from the <jats:italic>Ligustrum vicaryi<\/jats:italic> L. fruit and investigate its immunomodulatory and antioxidant activities. The <jats:italic>Ligustrum vicaryi<\/jats:italic> L. fruit polysaccharide (LVFP) was obtained by ultrasonic extraction, ethanol precipitation, macroporous resin separation, and dialysis bag purification. The physicochemical properties of the LVFP were elucidated using Fourier\u2010transform infrared spectrometry, high\u2010performance ion chromatography, and high\u2010performance gel filtration chromatography. The results indicated that the LVFP consisted of rhamnose, arabinose, galactose, and glucose in a ratio of 1.79\u2009:\u20097.55\u2009:\u20094.58\u2009:\u20091.54, and its molecular weight was 88,949\u2009Da. The immunomodulatory and antioxidant activities of the LVFP were investigated using a cyclophosphamide\u2010 (Cy\u2010) induced immunosuppressed mouse model. The results demonstrated that the LVFP significantly increased spleen and thymus indexes, enhanced the phagocytic function of neutrophils, activated B and T lymphocytes, and upregulated serum levels of IL\u201010 and TNF\u2010<jats:italic>\u03b1<\/jats:italic>. Moreover, we observed that the LVFP relieved Cy\u2010induced liver damage by increasing superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010px) levels. These results suggested that the LVFP has the immunomodulatory and antioxidant activities, therefore laying a foundation for the application of the LVFP in the pharmaceutical and functional food industries.<\/jats:p>","DOI":"10.1155\/2020\/5431350","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T23:31:48Z","timestamp":1584487908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Immunomodulatory and Antioxidant Activities of a Polysaccharide from <i>Ligustrum vicaryi<\/i> L. 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