{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:00:12Z","timestamp":1778695212109,"version":"3.51.4"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":335,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2019A020"],"award-info":[{"award-number":["2019A020"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The pathogenesis of invasive aspergillosis (IA) is still unknown, but its progression is rapid and mortality rate remains high. Bronchoalveolar lavage fluid (BALF) galactomannan (GM) analysis has been used to diagnose IA. This study is aimed at making an accurate estimate of the whole accuracy of BALF\u2010GM in diagnosing IA. <jats:italic>Methods<\/jats:italic>. After a systematic review of the study, a bivariate meta\u2010analysis was used to summarize the specificity (SPE), the sensitivity (SEN), the positive likelihood ratios (PLR), and the negative likelihood ratios (NLR) of BALF\u2010GM in diagnosing IA. The overall test performance was summarized using a layered summary receiver operating characteristic (SROC) curve. Subgroup analysis was performed to explore the heterogeneity between studies. <jats:italic>Results<\/jats:italic>. A total of 65 studies that are in line with the inclusion criteria were included. The summary estimates of BALF\u2010GM analysis are divided into four categories. The first is the proven+probable vs. possible+no IA, with an SPE, 0.87 (95% CI, 0.85\u20100.98); SEN, 0.81 (95% CI, 0.76\u20100.84); PLR, 9.78 (5.78\u201016.56); and NLR, 0.20 (0.14\u20100.29). The AUC was 0.94. The BALF\u2010GM test for proven+probable vs. no IA showed SPE, 0.88 (95% CI, 0.87\u20100.90); SEN, 0.82 (95% CI, 0.78\u20100.85); PLR, 6.56 (4.93\u20108.75); and NLR, 0.24 (0.17\u20100.33). The AUC was 0.93. The BALF\u2010GM test for proven+probable+possible vs. no IA showed SPE, 0.82 (95% CI, 0.79\u20100.95); SEN, 0.59 (95% CI, 0.55\u20100.63); PLR, 3.60 (2.07\u20106.25); and NLR, 0.31 (0.15\u20100.61). The AUC was 0.86. The analyses for others showed SPE, 0.85 (95% CI, 0.83\u20100.87); SEN, 0.89 (95% CI, 0.86\u20100.91); PLR, 6.91 (4.67\u201010.22); and NLR, 0.18 (0.13\u20100.26). The AUC was 0.94. <jats:italic>Conclusions<\/jats:italic>. The findings of this BALF\u2010GM test resulted in some impact on the diagnosis of IA. The BALF\u2010GM assay is considered a method for diagnosing IA with high SEN and SPE. However, the patients\u2019 underlying diseases may affect the accuracy of diagnosis. When the cutoff is greater than 1, the sensitivity will be higher.<\/jats:p>","DOI":"10.1155\/2020\/5434589","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T01:35:07Z","timestamp":1606872907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Accuracy of Bronchoalveolar Lavage Fluid Galactomannan for Invasive Aspergillosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xun-Jie","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Min","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Lang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-5234","authenticated-orcid":false,"given":"Xu-Guang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0714-4"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003743"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01506-15"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.10661"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010009"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70006-X"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd012399.pub2"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043347"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0488"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2019.03.014"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12881"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2019.2.22940"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.01.07"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12987"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-018-0618-z"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01877"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12704"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12694"},{"key":"e_1_2_10_23_2","first-page":"124","article-title":"Galactomannan tests of bronchoalveolar lavage fluid for diagnosing invasive pulmonary aspergillosis","volume":"49","author":"Deng J.","year":"2018","journal-title":"Sichuan da xue xue bao. 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