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Currently, there is no approved drug for its treatment. Improving lifestyle and exercise can alleviate symptoms, but patients\u2019 compliance is poor. More and more studies have shown the potential of Polygoni Multiflori Radix (PMR) in the treatment of NAFLD and metabolic syndrome. Therefore, this paper reviews the pharmacological effects of PMR and its main chemical components (tetrahydroxystilbene glucoside, emodin, and resveratrol) on NAFLD. PMR can inhibit the production of fatty acids and promote the decomposition of triglycerides, reduce inflammation, and inhibit the occurrence of liver fibrosis. At the same time, it maintains an oxidation equilibrium status in the body, to achieve the therapeutic purpose of NAFLD and metabolic syndrome. Although more standardized studies and clinical trials are needed to confirm its efficacy, PMR may be a potential drug for the treatment of NAFLD and its complications. However, the occurrence of adverse reactions of PMR has affected its extensive clinical application. Therefore, it is necessary to further study its toxicity mechanism, enhance efficacy and control toxicity, and even reduce toxicity, which will contribute to the safe clinical use of PMR.<\/jats:p>","DOI":"10.1155\/2020\/5462063","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T23:31:22Z","timestamp":1587598282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-4902","authenticated-orcid":false,"given":"Mengting","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-5444","authenticated-orcid":false,"given":"Meichen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-1197","authenticated-orcid":false,"given":"Ying","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-1170","authenticated-orcid":false,"given":"Linfeng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-1365","authenticated-orcid":false,"given":"Chaocheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-0453","authenticated-orcid":false,"given":"Xingtao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-4335","authenticated-orcid":false,"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,22]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2019.03.025"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44563-y"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50193"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.021"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00064.2004"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-019-00107-7"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.07.003"},{"key":"e_1_2_9_9_2","first-page":"299","article-title":"Relevant issues concerning clinical trials of traditional Chinese medicine treatment of nonalcoholic fatty liver disease","volume":"30","author":"Guang J.","year":"2014","journal-title":"Journal of Clinical Hepatology"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14161"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9050104"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105445"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2019.05.004"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.011"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-017-06926-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091153"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2298"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2298"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41583.x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150125"},{"key":"e_1_2_9_21_2","first-page":"203","article-title":"Nonalcoholic fatty liver disease effect of emodin based on AMPK signaling pathway","volume":"26","author":"Lin-yuan Y.","year":"2020","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.810"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.07.170"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-019-0242-0"},{"key":"e_1_2_9_25_2","article-title":"Apoptotic or antiproliferative activity of natural products against keratinocytes for the treatment of psoriasis","volume":"20","author":"Huang T. 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