{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:39:30Z","timestamp":1789184370051,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Evaluate the effects of carboxy\u2010methyl\u2010beta\u2010glucan on cervical epithelialization and on the vaginal microbiota in patients with HPV infection or low\u2010grade cervical preneoplastic lesion (CIN 1). <jats:italic>Materials and Methods<\/jats:italic>. Seven\u2010hundred eighty\u2010four women with positive HPV tests or diagnosed with CIN 1 were enrolled in a retrospective case\u2010control study. All the recruited women performed, at baseline and after 6 months, Pap test, HPV test, evaluation of vaginal health according to the Amsel criteria, colposcopy, and punch biopsy. The study population was then divided into 2 groups in relation to the therapy performed during the follow\u2010up period. Group A performed treatment with vaginal gel based on carboxy\u2010methyl\u2010beta\u2010glucan (1 application\/day for 20 days per month for 3 months). Group B was the control group. <jats:italic>Results<\/jats:italic>. The patients of group A had a significant improvement in the ectopia pattern and a greater number of cases with metaplasia in the maturation phase with a significant increase in Lugol uptake. In the experimental group, a significant improvement in the pH indices, a negative Swift test and a resolution of the leucorrhoea were observed. A negative result of the 37.1% Pap test and the 39.9% HPV test (vs. 15.2% and 16.5%, respectively) were demonstrated in the treatment group with respect to the control group. A negativization of the colposcopic pictures was observed with a reduction in the amount of CIN 1 found higher in the treatment group. <jats:italic>Conclusions<\/jats:italic>. Vaginal therapy based on carboxy\u2010methyl\u2010beta\u2010glucan has been able to improve overall vaginal health; this effect seemed to positively impact the risk of persistence and progression of CIN.<\/jats:p>","DOI":"10.1155\/2020\/5476389","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:34:39Z","timestamp":1588030479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects on Vaginal Microbiota Restoration and Cervical Epithelialization in Positive HPV Patients Undergoing Vaginal Treatment with Carboxy\u2010Methyl\u2010Beta\u2010Glucan"],"prefix":"10.1155","volume":"2020","author":[{"given":"Giada","family":"Lavitola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-2181","authenticated-orcid":false,"given":"Luigi","family":"Della 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