{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:24:29Z","timestamp":1790738669376,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972599"],"award-info":[{"award-number":["31972599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018NZDZX0005"],"award-info":[{"award-number":["2018NZDZX0005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Sichuan Province","award":["31972599"],"award-info":[{"award-number":["31972599"]}]},{"name":"Key Research and Development Program of Sichuan Province","award":["2018NZDZX0005"],"award-info":[{"award-number":["2018NZDZX0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,3,19]]},"abstract":"To explore the effect of selenium-enriched yeast (SeY) on intestinal barrier functions in weaned pigs upon oxidative stress, a 2<\/mml:mn>\u00d7<\/mml:mo>2<\/mml:mn><\/mml:math> factorial design was utilized and thirty-two pigs were randomly assigned into four groups. Pigs with or without exposure to oxidative stress (diquat challenge) were fed with a basal diet or a SeY-containing diet. The trial lasted for 21 days, and result showed that SeY supplementation attenuated body-weight reduction and significantly decreased the serum concentrations of diamine oxidase (DAO) and D-lactic acid in pigs upon diquat challenge (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). Diquat challenge decreased the villus height and the ratio of villus height to crypt depth (V\/C) in the jejunum and ileum (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). However, SeY supplementation not only elevated the villus height and the ratio of V\/C (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>) but also improved the distribution and abundance of tight-junction protein ZO-1 in the jejunum epithelium. Interestingly, SeY supplementation acutely decreased the total apoptosis rate of intestinal epithelial cells in pigs upon diquat challenge (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). Moreover, SeY elevated the content of antioxidant molecules such as glutathione peroxidase (GSH-Px) and catalase (CAT) but significantly decreased the content of malondialdehyde (MDA) in the intestinal mucosa (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). Importantly, SeY elevated the expression levels of critical functional genes such as the nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), sodium\/glucose cotransporter 1 (SGLT1), and B-cell lymphoma-2 (BCL-2) in the intestinal mucosa upon diquat challenge (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). Moreover, the expression of caspase-3 was downregulated by SeY in the duodenum and jejunum mucosa (P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). These results indicated that SeY attenuated oxidative stress-induced intestinal mucosa disruption, which was associated with elevated mucosal antioxidative capacity and improved intestinal barrier functions.<\/jats:p>","DOI":"10.1155\/2020\/5490743","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T23:31:47Z","timestamp":1584660707000},"page":"1-11","source":"Crossref","is-referenced-by-count":51,"title":["Selenium-Enriched Yeast Alleviates Oxidative Stress-Induced Intestinal Mucosa Disruption in Weaned Pigs"],"prefix":"10.1155","volume":"2020","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan Province, Chengdu 611130, China"},{"name":"Key Laboratory of Animal Disease-Resistant Nutrition, Sichuan Province, Chengdu 611130, 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