{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:14:55Z","timestamp":1765610095972,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":254,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFC1707407"],"award-info":[{"award-number":["2018YFC1707407"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Tension\u2010type headache (TTH) is the most common headache disorder. Current treatments for TTH have been reported to be associated with insufficient long\u2010term benefits and unwanted adverse events (AEs). The Chinese herbal formula Xuefu Zhuyu (XFZY) has been utilized in TTH treatment, but the evidence supporting its efficacy remains unclear. This study will evaluate the efficacy and safety of XFZY for TTH. <jats:italic>Methods<\/jats:italic>. This multicenter, double\u2010blind, randomized, placebo\u2010controlled trial will be undertaken in China. A total of 174 eligible participants will be randomly assigned to either an XFZY group or a placebo group (20\u2009ml each dose, three times daily for 4 weeks) at a ratio of 1\u2009:\u20091. The primary outcome is the change in mean headache intensity measured by a 10\u2009cm visual analogue scale (VAS). Secondary outcomes include the area\u2010under\u2010the headache curve (AUC), headache frequency, rescue medication use, <jats:italic>qi-stagnation and blood-stasis<\/jats:italic> pattern measurement, quality of life measured by the EuroQol\u20105\u2010Dimensions\u20105\u2010Level (EQ\u20105D\u20105L), global evaluation of medication, and health economic indexes. <jats:italic>Discussion<\/jats:italic>. The results of the study are expected to provide evidence of high methodological and reporting quality on the efficacy and safety of XFZY for TTH. This trail is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/showprojen.aspx?proj=44489\">ChiCTR1900026716<\/jats:ext-link> (registered on 19 October, 2019).<\/jats:p>","DOI":"10.1155\/2020\/5653169","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T23:36:58Z","timestamp":1599867418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chinese Herbal Formula Xuefu Zhuyu for Tension\u2010Type Headache with <i>Qi<\/i>\u2010Stagnation and Blood\u2010Stasis Pattern (CheruXTH): Study Protocol for a Randomized Controlled Trial"],"prefix":"10.1155","volume":"2020","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-2248","authenticated-orcid":false,"given":"Li","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-2047","authenticated-orcid":false,"given":"Zehuai","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13067"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1048-2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-13"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-005-3778-5"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000227043.00824.a9"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03070.x"},{"volume-title":"Guidelines for All Healthcare Professionals in the Diagnosis and Management of Migraine, Tension-type, Cluster and Medication-Overuse Headache","author":"Steiner T. 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