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Neurodegeneration is a common pathway of assorted processes, including activation of inflammatory pathways, reduction of neuroprotective factors, DNA damage, and apoptosis. Oxidative stress and formation of advanced glycation end products amplify these processes and are elevated in the setting of hyperglycemia, hyperlipidemia, and glucose variability. These key pathophysiologic mechanisms are discussed, as well as diagnostic modalities and novel therapeutic avenues, with an emphasis on recent discoveries. The aim of this article is to highlight the crucial role of neurodegeneration in diabetic retinopathy and to review the molecular basis for this neuronal dysfunction, its diagnostic features, and the progress currently made in relevant therapeutic interventions.<\/jats:p>","DOI":"10.1155\/2020\/5728674","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T14:27:07Z","timestamp":1607437627000},"page":"1-13","source":"Crossref","is-referenced-by-count":31,"title":["Recent Developments in Diabetic Retinal Neurodegeneration: A Literature Review"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-5150","authenticated-orcid":true,"given":"Shani","family":"Pillar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Moisseiev","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelizaveta","family":"Sokolovska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Latvia, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Grzybowski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland"},{"name":"Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-015-0026-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30393-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00023-X"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00222.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1134-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522014113"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.03.003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21873"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3548-y"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.036376"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1304571"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3260"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0927"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.033548"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4692-1"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.04.013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6293"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.266910"},{"issue":"7","key":"19","first-page":"1971","article-title":"Glial reactivity, an early feature of diabetic retinopathy","volume":"41","author":"E. 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