{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:37:27Z","timestamp":1761824247321,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":320,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To identify the incidence of ovarian metastasis and the impact of ovarian preservation on oncological outcomes for early\u2010stage adenocarcinoma and adenosquamous cervical cancer. <jats:italic>Methods<\/jats:italic>. 281 patients with stages IA2\u2010IB1 adenocarcinoma and adenosquamous cervical cancer who underwent radical hysterectomy with pelvic lymphadenectomy (RHND) were included in the study. The incidence of ovarian metastasis was evaluated from 173 patients who underwent oophorectomy during RHND. Subgroup analysis was performed for patients less than 50 years (196 of 281 patients) who were classified into two groups, ovarian preservation and nonovarian preservation groups. 5\u2010year recurrence\u2010free survival (5\u2010yr RFS) and 5\u2010year overall survival (5\u2010yr OS) were evaluated and compared between these groups. <jats:italic>Results<\/jats:italic>. There was no evidence of ovarian metastasis, synchronous ovarian cancer, or ovarian recurrence during follow\u2010up. In patients less than 50 years of age, there were no statistically significant differences in the 5\u2010yr RFS (<jats:italic>P<\/jats:italic> = 0.363), or 5\u2010yr OS (<jats:italic>P<\/jats:italic> = 0.974) between the ovarian preservation and nonovarian preservation groups. In Kaplan\u2013Meier analysis, the ovarian preservation group seemed to have a slightly better OS in long\u2010term follow\u2010up (after 15 years); however, the difference was not statistically significant. <jats:italic>Conclusions<\/jats:italic>. Ovarian preservation was safe in adenocarcinoma and adenosquamous cervical cancer stages IA2\u2010B1. However, the impact of ovarian preservation on oncological outcomes needs to be further investigated.<\/jats:p>","DOI":"10.1155\/2020\/5791381","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:17:05Z","timestamp":1605601025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and Prognostic Impacts of Ovarian Preservation during Radical Hysterectomy for Early\u2010Stage Adenocarcinoma and Adenosquamous Cervical 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