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To investigate whether exercise preconditioning (EP) improves the rat cardiac dysfunction induced by exhaustive exercise (EE) through regulating NOD\u2010like receptor protein 3 (NLRP3) inflammatory pathways and to confirm which intensity of EP is better. <jats:italic>Method<\/jats:italic>. Ninety healthy male Sprague Dawley rats were randomly divided into five groups: a control group (CON), exhaustive exercise group (EE), low\u2010, middle\u2010, and high\u2010intensity exercise precondition and exhaustive exercise group (LEP\u2009+\u2009EE, MEP\u2009+\u2009EE, HEP\u2009+\u2009EE group). We established the experimental model by referring to Bedford\u2019s motion load standard to complete the experiment. Then, the pathological changes of the myocardium were observed under a light microscope. Biomarker of myocardial injury in serum and oxidative stress factor in myocardial tissue were evaluated by ELISAs. The cardiac function parameters were detected using a Millar pressure and volume catheter. The levels of thioredoxin\u2010interacting protein (TXNIP), thioredoxin protein (TRX), nuclear transcription factor kappa B<jats:sub>p65<\/jats:sub> (NF\u2010\u0138B<jats:sub>p65<\/jats:sub>), NLRP3, and cysteinaspartate specific proteinase 1 (Caspase\u20101) protein in rats\u2019 myocardium were detected by western blotting. <jats:italic>Results<\/jats:italic>. 1. The myocardial structures of three EP\u2009+\u2009EE groups were all improved compared with EE groups. 2. The levels of the creatine phosphating\u2010enzyme MB (CK\u2010MB), reactive oxygen species (ROS), interleukin\u20106 (IL\u20106), C\u2010reactive protein (CRP), and tumor necrosis factor alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) in three EP\u2009+\u2009EE groups were all increased compared with CON but decreased compared with the EE group (<jats:italic>P<\/jats:italic> &lt; 0.05). 3. Compared with the CON group, slope of end\u2010systolic pressure volume relationship (ESPVR), ejection fraction (EF), and peak rate of the increase in pressure (d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub>) all dropped to the lowest level in the EE group (<jats:italic>P<\/jats:italic> &lt; 0.05), while the values of cardiac output (CO), stroke volume (SV), end\u2010systolic volume (Ves), end\u2010diastolic volume (Ved), and relaxation time constant (Tau) increased in the EE group (<jats:italic>P<\/jats:italic> &lt; 0.05). 4. Compared with the CON group, the expression levels of TXNIP, NF\u2010\u0138B<jats:sub>p65<\/jats:sub>, NLRP3, and Caspase\u20101 all increased obviously in the other groups (<jats:italic>P<\/jats:italic> &lt; 0.05); meanwhile, they were all decreased in three EP\u2009+\u2009EE groups compared with the EE group (<jats:italic>P<\/jats:italic> &lt; 0.05). 5. NLRP3 was positively correlated with heart rate, IL\u20106, and ROS, but negatively correlated with EF (<jats:italic>P<\/jats:italic> &lt; 0.01). <jats:italic>Conclusion<\/jats:italic>. EP protects the heart from EE\u2010induced injury through downregulating TXNIP\/TRX\/NF\u2010\u0138B<jats:sub>p65<\/jats:sub>\/NLRP3 inflammatory signaling pathways. Moderate intensity EP has the best protective effect.<\/jats:p>","DOI":"10.1155\/2020\/5809298","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T23:31:17Z","timestamp":1591745477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIP\/TRX\/NF\u2010\u0138B<sub>p65<\/sub>\/NLRP3 Inflammatory Pathways"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yuemin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-7204","authenticated-orcid":false,"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-6905","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-9843","authenticated-orcid":false,"given":"Junshi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-8854","authenticated-orcid":false,"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9056-1826","authenticated-orcid":false,"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-0609","authenticated-orcid":false,"given":"Heling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-0775","authenticated-orcid":false,"given":"Xuebin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.134"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12065"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8060196"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0542-4"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00030.2013"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.066"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep22759"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.015"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.088"},{"key":"e_1_2_10_10_2","first-page":"242","article-title":"Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: possible involvement of NLRP3 inflammasome and NF-\u03baB signaling pathway","volume":"23","author":"Yin Y.","year":"2017","journal-title":"Molecular Vision"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.001"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116631"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486115"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188387"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1987149"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00461.2017"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12773"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12323"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-16-0949"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002353"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1090-7"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.6.1278"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.138"},{"key":"e_1_2_10_24_2","first-page":"270","article-title":"A clinical study of exhaustive cardiac injury in a combat zone","volume":"20","author":"Wang X. 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