{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:30Z","timestamp":1792787550050,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects of Guangdong Traditional Chinese Medicine Bureau","award":["20183002"],"award-info":[{"award-number":["20183002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Cervical spondylosis (CS) refers to the degenerative changes in the cervical spinal column, which affect the majority of middle\u2010aged and elderly people. Thunder\u2010fire moxibustion originated from thunder\u2010fire miraculous needle, which has been applied widely for treating pain syndromes for thousands of years. The aim of our research is to provide evidence to assess the efficacy and safety of thunder\u2010fire moxibustion in treating CS.\n                    <jats:italic>Methods and analysis.<\/jats:italic>\n                    Retrieved literature databases included Cochrane Library, MEDLINE, Web of Science, EBSCO, EBASE, Springer, PubMed, WFDP, CNKI, VIP, and CBM. The period of retrieval was from the establishment of the database to December 2018. Randomized controlled trials which compared thunder\u2010fire moxibustion and other therapies in CS were included. The quality of inclusive trials was accessed though a Cochrane risk of bias tool. According to the test results of heterogeneity, a random effect model or fixed effect model was used to analyze the data.\n                    <jats:italic>Results<\/jats:italic>\n                    . Meta\u2010analysis was conducted for the total effective rate of thunder\u2010fire moxibustion, traditional Chinese medicine syndrome score, pain score, satisfaction score, and score of the symptoms and functional rehabilitation of cervical vertigo. The analysis results were as follows: compared with other therapies, the efficacy of thunder\u2010fire moxibustion was statistically significant, total effective rate increased (OR\u2009=\u20092.48; 95% CI [1.80, 3.41];\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.00001), traditional Chinese medicine syndrome score decreased (SMD\u2009=\u2009\u22123.05; 95% CI[\u22124.18, \u22121.93];\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.00001), pain score decreased (SMD\u2009=\u2009\u22120.91; 95% CI [\u22121.79, \u22120.03];\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004), satisfaction score increased (SMD\u2009=\u20095.35, 95% CI [2.72, 7.98];\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), and score of the symptoms and functional rehabilitation of cervical vertigo increased (SMD\u2009=\u20094.10, 95% CI [2.34, 5.87];\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.00001). The level of evidence was very low.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Based on the existing evidence, the curative effect and safety of thunder\u2010fire moxibustion on CS were statistically significant. We should interpret the results scrupulously because of the low evidence level. Large\u2010scale, high\u2010quality, rigorous RCTs with long\u2010term follow\u2010up should be performed in the future.\n                  <\/jats:p>","DOI":"10.1155\/2020\/5816717","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T18:31:27Z","timestamp":1581445887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thunder\u2010Fire Moxibustion for Cervical Spondylosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Ruina","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-5815","authenticated-orcid":false,"given":"Danghan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-8354","authenticated-orcid":false,"given":"Xinghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000000524"},{"key":"e_1_2_11_2_2","first-page":"1755","article-title":"Cervical 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