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We have performed a systematic review of different sterilization and disinfection procedures aiming at drawing up a disinfection and sterilization procedure to be used on endodontic instruments. A search on PubMed and Scopus was carried out using the following keywords: \u201cendodontic sterilization,\u201d \u201cendodontic autoclave,\u201d \u201cdecontamination dental bur,\u201d \u201csterilization dental burs,\u201d and \u201cgutta-percha points sterilization.\u201d Eligible articles were included in the qualitative and quantitative analysis. Results of the meta-analysis showed that the most effective method in sterilization is autoclaving. The qualitative analysis showed that the use of single-use or first-use instruments requires presterilization or sterilization procedures, and for reusable tools, attention must be paid to the removal of debris deposited on the blades, not easy to remove manually.<\/jats:p>","DOI":"10.1155\/2020\/5824369","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T18:31:46Z","timestamp":1581359506000},"page":"1-20","source":"Crossref","is-referenced-by-count":28,"title":["Management of Instrument Sterilization Workflow in Endodontics: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-3457","authenticated-orcid":true,"given":"Mario","family":"Dioguardi","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, 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