{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:43:55Z","timestamp":1792741435511,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,7,29]]},"abstract":"<jats:p>Using a surgically induced varicocele rat model, we show here strong evidence that the misfolded\/unfolded protein response that is part of the stress response of the endoplasmic reticulum (ER) is activated in the varicocele testis (VCL), leading to the induction of apoptosis. To support this hypothesis, it is observed that the spliced variant of the X-box protein 1 (XBP1s), resulting from the activation of the inositol-requiring enzyme 1 (IRE1) membrane sensor, is significantly more represented in VCL testicular extracts. The activation of the IRE1\/XBP1s pathway is also supported by the observation that the VCL testes show an increase phosphorylation of the c-Jun-kinase (JNK) known to be one intermediate of this pathway and an increased level of caspase-3, the terminal apoptotic effector, partly explaining the apoptotic status of the VCL testis.<\/jats:p>","DOI":"10.1155\/2020\/5909306","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T23:41:50Z","timestamp":1596066110000},"page":"1-11","source":"Crossref","is-referenced-by-count":35,"title":["Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model"],"prefix":"10.1155","volume":"2020","author":[{"given":"Mahshid","family":"Hosseini","sequence":"first","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfaneh","family":"Shaygannia","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Eskandari","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram Ahmadzadeh","family":"Golsefid","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziyeh","family":"Tavalaee","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Gharagozloo","sequence":"additional","affiliation":[{"name":"Celloxess LLC, 830 Bear Tavern Road, Ewing, NJ 08628, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-6558","authenticated-orcid":true,"given":"Jo\u00ebl R.","family":"Drevet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-3435","authenticated-orcid":true,"given":"Mohammad H.","family":"Nasr-Esfahani","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2013.08.001"},{"issue":"3","key":"2","first-page":"99","volume":"11","year":"2007","journal-title":"Hippokratia"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.172819"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.172640"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03253-8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12511"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.198"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1071\/RD15325"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2003.11.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401778"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.056"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407704-1.00005-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023740"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401840"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr143"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104649"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms009"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119386"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.09.082"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr232"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2019.01.001"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-013-1157-0"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.17221\/8384-VETMED"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2010.51.8.565"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22345"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/and.13085"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14385"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43038-4"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0372-8"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal119"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47963-X"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-7675-7_46"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009406231811"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/ni907"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.06.005"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-3088-0"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.22037\/uj.v0i0.4740"},{"issue":"11","key":"39","first-page":"1025","volume":"23","year":"2017","journal-title":"Zhonghua Nan Ke Xue"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8020"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0885-7"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-012-0351-5"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24360"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.04.032"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310335200"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.301"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.179127"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh003"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1439-z"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2012.129"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.02.014"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.19.5708"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.01.039"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1101\/gad.238246.114"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7383-5"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/SO168-8278(03)00029-1"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.100860"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2736-9"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.017"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006618"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225785"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00210-1"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/5909306.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/5909306.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/5909306.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T23:34:55Z","timestamp":1596238495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/5909306\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":62,"alternative-id":["5909306","5909306"],"URL":"https:\/\/doi.org\/10.1155\/2020\/5909306","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]}}}