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Acupuncture has a therapeutic effect on inflammatory pain. However, whether H<jats:sub>2<\/jats:sub>S generated in the central nervous system (CNS) is a mediator of electroacupuncture (EA) treatment for inflammatory pain is unknown. We injected complete Freund\u2019s adjuvant (CFA) to induce inflammatory pain and applied EA treatment as an interventional strategy for pain relief. The results presented here show that S\u2010adenosyl\u2010l\u2010methionine (SAM), an allosteric activator of cystathionine\u2010<jats:italic>\u03b2<\/jats:italic>\u2010synthetase (CBS), may reverse the therapeutic effect of EA. 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