{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:53:46Z","timestamp":1764251626450,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Zurich, Switzerland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Actinomycosis is a chronic suppurative infection primarily caused by anaerobic gram\u2010positive filamentous bacteria, primarily of the genus Actinomyces. Oral\u2010cervicofacial actinomycosis is the localization found most often, presenting as a soft tissue swelling, an abscess, a mass lesion, or sometimes an ulcerative lesion. Periodontitis\u2010like lesions, however, are rare findings. This report describes the case of a 41\u2010year\u2010old healthy female patient (nonsmoker), who was referred to the clinic with dull and throbbing pain in the second quadrant. Tooth 25 showed increased mobility and probing pocket depths up to 10\u2009mm, with profuse bleeding upon probing. Radiographically, considerable interproximal horizontal bone loss was found, and the diagnosis of periodontitis stage 3, grade C was made. The situation was initially stabilized with adhesive splinting and local anti\u2010infective therapy. Two weeks later, the bone defect was treated with guided tissue regeneration (GTR) using a xenogenic filler material (BioOss Collagen) and a resorbable membrane (Bio\u2010Gide). Due to a suspicious appearance of the excised granulation tissue, the collected fragments were sent for histopathological evaluation. This evaluation revealed a chronic granulomatous inflammation with the presence of filamentous bacterial colonies, consistent with Actinomyces. The patient was successfully treated. While there are only few reports in the literature, actinomycotic lesions represent a rare but possible finding in cases with localized periodontal destruction. In conclusion, systematic biopsy of the infrabony tissue in localized periodontal lesions may help to provide a more accurate counting of Actinomyces\u2010associated lesions, thereby improving diagnosis, therapy, and prevention.<\/jats:p>","DOI":"10.1155\/2020\/5961452","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T18:30:55Z","timestamp":1580754655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Actinomycosis as a Rare Local Manifestation of Severe Periodontitis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Moody","family":"Kaldas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Barghorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-0325","authenticated-orcid":false,"given":"Patrick R.","family":"Schmidlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1086\/516337"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.45.39"},{"key":"e_1_2_8_3_2","first-page":"331","article-title":"Cervicofacial actinomycosis: CT and MR imaging findings in seven patients","volume":"24","author":"Park J. 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