{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:09Z","timestamp":1747190349735,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T00:00:00Z","timestamp":1582329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2020,2,22]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This work aimed to study the efficacy of hybrid <jats:sup>99m<\/jats:sup>Tc-Pyrophosphate SPECT\/CT for diagnosis of latent inflammatory processes in the myocardium of patients with atrial fibrillation (AF). <jats:italic>Methods<\/jats:italic>. The study comprised 34 patients aged 44\u2009\u00b1\u20099 years with AF of unknown etiology referred for radiofrequency ablation. The data were acquired using hybrid <jats:sup>99m<\/jats:sup>Tc-Pyrophosphate SPECT\/CT. To evaluate and interpret the results of hybrid study and to determine localization of radiopharmaceutical accumulation, scintigraphic and CT images were fused. SPECT\/CT results were compared with data of endomyocardial biopsy. <jats:italic>Results<\/jats:italic>. Sensitivity, specificity, and accuracy of <jats:sup>99m<\/jats:sup>Tc-Pyrophosphate SPECT\/CT in diagnosing myocarditis were 91%, 100%, and 94%, respectively. Proposed diagnostic criteria for myocarditis comprised intensity of the radiopharmaceutical accumulation in the myocardium and the ratios of focus\/lung, focus\/vertebral column, and focus\/LV pool. Minimum cutoff values for the histologically verified myocarditis were &gt;1.47 for focus\/lung index, &gt;0.11 for focus\/vertebral column ratio, and &gt;1.26 for focus\/lung index. <jats:italic>Conclusions<\/jats:italic>. SPECT\/CT-based quantitative assessment of <jats:sup>99m<\/jats:sup>Tc-Pyrophosphate accumulation in the myocardium is a highly informative noninvasive method for diagnosis of inflammatory process in the heart in patients with AF of undefined etiology.<\/jats:p>","DOI":"10.1155\/2020\/5983751","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T18:31:00Z","timestamp":1582396260000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Efficacy of Cardiac Scintigraphy with <sup>99m<\/sup>Tc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-3648","authenticated-orcid":true,"given":"Julia","family":"Ilyushenkova","sequence":"first","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 111a Kievskaya Str., Tomsk 634012, 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