{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:19:22Z","timestamp":1777357162210,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2019JJ50264"],"award-info":[{"award-number":["2019JJ50264"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2017YF D0500506"],"award-info":[{"award-number":["2017YF D0500506"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["31802074"],"award-info":[{"award-number":["31802074"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["31772617"],"award-info":[{"award-number":["31772617"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2019JJ50264"],"award-info":[{"award-number":["2019JJ50264"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YF D0500506"],"award-info":[{"award-number":["2017YF D0500506"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["31802074"],"award-info":[{"award-number":["31802074"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["31772617"],"award-info":[{"award-number":["31772617"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019JJ50264"],"award-info":[{"award-number":["2019JJ50264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YF D0500506"],"award-info":[{"award-number":["2017YF D0500506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802074"],"award-info":[{"award-number":["31802074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772617"],"award-info":[{"award-number":["31772617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019JJ50264"],"award-info":[{"award-number":["2019JJ50264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YF D0500506"],"award-info":[{"award-number":["2017YF D0500506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802074"],"award-info":[{"award-number":["31802074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772617"],"award-info":[{"award-number":["31772617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,2,10]]},"abstract":"<jats:p>This study was conducted to evaluate the effect of dietary supplementation with <jats:italic>Lactobacillus delbrueckii<\/jats:italic> (LAB) on intestinal morphology, barrier function, immune response, and antioxidant capacity in weaned piglets challenged with lipopolysaccharide (LPS). A total of 36 two-line crossbred (Landrace\u2009\u00d7\u2009large Yorkshire) weaned piglets (28 days old) were divided into three groups: (1) nonchallenged control (CON); (2) LPS-challenged control (LPS); and (3) LAB+LPS treatment (0.2% LAB+LPS). Compared to the LPS piglets, the LAB+LPS piglets improved intestinal morphology, indicated by greater (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) villus height in the duodenum and ileum; villus height\u2009:\u2009crypt depth ratio in the duodenum, jejunum, and ileum, as well as decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) crypt depth in the jejunum and ileum; and better intestinal barrier function, indicated by upregulated (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) mRNA expression of tight junction proteins in the intestinal mucosa. Moreover, compared to the LPS piglets, LAB significantly decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) concentrations of TNF-<jats:italic>\u03b1<\/jats:italic> and IL-1<jats:italic>\u03b2<\/jats:italic> in the small intestine and increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) IL-10 levels in the jejunum and ileum. Additionally, LAB increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) T-AOC activities of the colon, GSH concentrations of the jejunum, and mRNA expression of CAT and Cu\/Zn-SOD, while reduced (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) MDA concentrations in the jejunum and ileum in LPS-changed piglets. Collectively, our results indicate that supplementation of LAB improved intestinal integrity and immune response and alleviated intestinal oxidative damage in LPS-challenged piglets.<\/jats:p>","DOI":"10.1155\/2020\/6028606","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T18:30:53Z","timestamp":1581359453000},"page":"1-10","source":"Crossref","is-referenced-by-count":22,"title":["<i>Lactobacillus delbrueckii<\/i> Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-819X","authenticated-orcid":true,"given":"Fengming","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-5582","authenticated-orcid":true,"given":"Houjun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-4607","authenticated-orcid":true,"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3806-6318","authenticated-orcid":true,"given":"Xingguo","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University, Changsha Hunan 410128, China"},{"name":"Hunan Co-Innovation Center of Animal Production Safety (CICAPS), Changsha Hunan 410128, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"issue":"2","key":"2","first-page":"132","volume":"11","year":"2013","journal-title":"Journal of Food, Agriculture and Environment"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2741\/e463"},{"issue":"6","key":"4","first-page":"746","volume":"101","year":"1987","journal-title":"Surgery"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2019.108585"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-19"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-4444"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001608"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA13557A"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1042\/bj20050959"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4530"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.99"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6919803"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/66470\/2008"},{"key":"18","year":"2012"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513002171"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2016.0911"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2011.07.005"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.01.005"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2006.09.003"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.07.020"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.15.0066"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2012-02845"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.164947"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0473-y"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508911612"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5796"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.08.007"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2017.05.006"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1021\/jf403288r"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0372-1"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-8330"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2005.08.005"},{"issue":"3","key":"38","first-page":"220","volume":"13","year":"2016","journal-title":"Iranian Journal of Immunology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.5.659"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1017\/s0031182001007399"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507257770"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-1991-9"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.03.014"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2017.06.012"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1113\/JP271543"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-010-1255-1"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2009.04294.x"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2013-0680"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050521"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/6028606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/6028606.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/6028606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T18:31:03Z","timestamp":1581359463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/6028606\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":50,"alternative-id":["6028606","6028606"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6028606","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]}}}