{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:07:51Z","timestamp":1780470471418,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,1,13]]},"abstract":"<jats:p>Malaria in pregnancy causes adverse birth outcomes due to sequestration of <jats:italic>Plasmodium falciparum<\/jats:italic>-infected erythrocytes in the placenta. Angiopoietins are critical regulators of vascular development and formation of placental villous vasculature. Angiopoietin-1 and Angiopoietin-2 concentrations were measured in peripheral and placental plasma samples from 70 malaria-infected and 216 control women using commercially available DuoSet ELISA development kit. Angiopoietins increased in placental plasma (ANG1-5833.5\u2009pg\/ml and ANG2-9580.6\u2009pg\/ml) as compared to peripheral plasma (ANG1-2293.1\u2009pg\/ml and ANG2-1198.9\u2009pg\/ml, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). The concentration of placental and peripheral ANG1 (6099.23\u2009pg\/ml and 2320.5\u2009pg\/ml) was significantly lower (5013.5\u2009pg\/ml, 2208.5\u2009pg\/ml), and ANG2 (9553.3\u2009pg\/ml, 1180.92\u2009pg\/ml) was significantly higher (9664.6\u2009pg\/ml, 1254.4\u2009pg\/ml) in malaria-positive cases as compared to malaria-negative (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). The association of dysregulated angiopoietins in malaria with adverse birth outcomes showed that the peripheral and placental ANG1 concentration was lower and ANG2 concentration was higher in low-birth-weight baby and stillbirth birth outcome as compared to normal deliveries among malaria-positive group. Therefore, ANG1 and ANG2 could be considered a biomarker for adverse outcome during malaria in pregnancy.<\/jats:p>","DOI":"10.1155\/2020\/6163487","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T18:31:27Z","timestamp":1578940287000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes"],"prefix":"10.1155","volume":"2020","author":[{"given":"Puspendra P.","family":"Singh","sequence":"first","affiliation":[{"name":"National Institute of Research in Tribal Health (NIRTH), 482003, Jabalpur, Madhya Pradesh, India"},{"name":"Department of Biological Science, University of Notre Dame, South Bend IN-46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Bhandari","sequence":"additional","affiliation":[{"name":"National Institute of Research in Tribal Health (NIRTH), 482003, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravendra K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"National Institute of Research in Tribal Health (NIRTH), 482003, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeru","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute of Research in Tribal Health (NIRTH), 482003, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-6869","authenticated-orcid":true,"given":"Praveen K.","family":"Bharti","sequence":"additional","affiliation":[{"name":"National Institute of Research in Tribal Health (NIRTH), 482003, Jabalpur, Madhya Pradesh, 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