{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:03:37Z","timestamp":1767992617892,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Bureau Project of Jilin City","award":["201830557"],"award-info":[{"award-number":["201830557"]}]},{"name":"Science and Technology Bureau Project of Jilin City","award":["2017ZC029"],"award-info":[{"award-number":["2017ZC029"]}]},{"name":"Jilin Provincial Health Department in China","award":["201830557"],"award-info":[{"award-number":["201830557"]}]},{"name":"Jilin Provincial Health Department in China","award":["2017ZC029"],"award-info":[{"award-number":["2017ZC029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>Primary immune thrombocytopenia (ITP) is an autoimmune disease. However, the molecular mechanisms underlying ITP remained to be further investigated. In the present study, we analyzed a series of public datasets (including GSE43177 and GSE43178) and identified 468 upregulated mRNAs, 272 downregulated mRNAs, 134 upregulated lncRNAs, 23 downregulated lncRNAs, 29 upregulated miRNAs, and 39 downregulated miRNAs in ITP patients. Then, we constructed protein-protein interaction networks, miRNA-mRNA and lncRNA coexpression networks in ITP. Bioinformatics analysis showed these genes regulated multiple biological processes in ITP, such as mRNA nonsense-mediated decay, translation, cell-cell adhesion, proteasome-mediated ubiquitin, and mRNA splicing. We thought the present study could broaden our insights into the mechanism underlying the progression of ITP and provide a potential biomarker for the prognosis of ITP.<\/jats:p>","DOI":"10.1155\/2020\/6193593","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T23:45:40Z","timestamp":1593560740000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Systematic Identification of lncRNA-Associated ceRNA Networks in Immune Thrombocytopenia"],"prefix":"10.1155","volume":"2020","author":[{"given":"Zhenwei","family":"Fan","sequence":"first","affiliation":[{"name":"Nursing College of Beihua University, Jilin 132013, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-543X","authenticated-orcid":true,"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Affiliated Hospital of Beihua University, Jilin 132013, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-932X","authenticated-orcid":true,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jilin Central Hospital, Jilin 132000, China"}]},{"given":"Chunli","family":"Mei","sequence":"additional","affiliation":[{"name":"Nursing College of Beihua University, Jilin 132013, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-3012","authenticated-orcid":true,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nursing College of Beihua University, Jilin 132013, China"}]},{"given":"Chunshan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nursing College of Beihua University, Jilin 132013, China"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Nursing College of Beihua University, Jilin 132013, China"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321398"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.03.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-2-1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3074"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201489589"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12934"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1475"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8715-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5504"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-471250"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6360"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1056"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.01.001"},{"issue":"5","key":"16","first-page":"1607","volume":"149","year":"1996","journal-title":"American Journal of Pathology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00405-3"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6193593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6193593.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6193593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T23:45:47Z","timestamp":1593560747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2020\/6193593\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":17,"alternative-id":["6193593","6193593"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6193593","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]}}}