{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:07:53Z","timestamp":1781298473652,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":261,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2015FY111100"],"award-info":[{"award-number":["2015FY111100"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2016YFC0900802"],"award-info":[{"award-number":["2016YFC0900802"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2015FY111100"],"award-info":[{"award-number":["2015FY111100"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2016YFC0900802"],"award-info":[{"award-number":["2016YFC0900802"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Previous studies confirmed that chronic arsenic exposure could lead to pigmentary changes and hyperkeratosis. However, skin health\u2010related quality of life (HRQoL) among people under lifetime arsenic exposure remains underappreciated. Our study is aimed at investigating several patient\u2010reported outcomes in a population under chronic arsenic exposure. <jats:italic>Patients and Methods<\/jats:italic>. A cross\u2010sectional study was conducted in communities in Shimen, China. Dermatologists performed skin examinations for participants. Patient\u2010reported outcomes (PROs) included HRQoL, itch, sleep quality, and symptoms of anxiety and depression. The Dermatology Life Quality Index (DLQI) was used to measure skin HRQoL. The numerical rating scale (NRS) was used to measure the intensity of itching. Sleep disturbance was measured by Pittsburgh Sleep Quality Index (PSQI). Anxiety and depression were measured by two\u2010item Generalized Anxiety Disorder (GAD\u20102) and Patient Health Questionnaire (PHQ\u20102), respectively. <jats:italic>Results<\/jats:italic>. A total of 464 participants suffering from arsenic\u2010related skin lesions finished the assessment of DLQI. Pigmentary changes and arsenical keratosis were not associated with the patient\u2010reported outcomes except PHQ\u20102. Hair arsenic exceeding 1\u2009<jats:italic>\u03bc<\/jats:italic>g\/g was associated with higher itch NRS and DLQI (<jats:italic>P<\/jats:italic> &lt; 0.05). Itch NRS (adjusted <jats:italic>\u03b2<\/jats:italic> = 0.80, 95% CI: 0.70\u20130.90, <jats:italic>P<\/jats:italic> &lt; 0.01) and hair arsenic concentration (adjusted <jats:italic>\u03b2<\/jats:italic> = 0.12, 95% CI: 0.01\u20130.24, <jats:italic>P<\/jats:italic> &lt; 0.05) were independently associated with the DLQI. <jats:italic>Conclusion<\/jats:italic>. HRQoL, sleep quality, and mental wellbeing are impaired in residents under chronic arsenic exposure. Itching and hair arsenic are independent risk factors for impaired HRQoL.<\/jats:p>","DOI":"10.1155\/2020\/6195975","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T23:31:50Z","timestamp":1600471910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Patient\u2010Reported Outcomes of Arsenic\u2010Related Skin Lesions in China"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-087X","authenticated-orcid":false,"given":"Yajia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danrong","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-8378","authenticated-orcid":false,"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-0111","authenticated-orcid":false,"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5538"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.031308.100143"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws366"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj154"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jes.7500510"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.477"},{"key":"e_1_2_13_7_2","first-page":"453","article-title":"Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan","volume":"40","author":"Tseng W. P.","year":"1968","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402426"},{"key":"e_1_2_13_9_2","first-page":"504","article-title":"Arsenic trioxide in patients with refractory multiple myeloma: a prospective, phase II, single-arm study","volume":"49","author":"Sanaat Z.","year":"2011","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1969-2"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.531"},{"key":"e_1_2_13_12_2","volume-title":"Environmental health criteria 18 - Arsenic","author":"WHO","year":"1981"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701142"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6195975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6195975.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/6195975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T06:27:34Z","timestamp":1735626454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/6195975"}},"subtitle":[],"editor":[{"given":"Arjen F.","family":"Nikkels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/6195975"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6195975","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6195975"}}