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Acellular matrix (AM) therapy has shown promise in the treatment of diabetic foot ulcers (DFUs) in several studies. The clinical effects of AM therapy were not well established. Therefore, we conducted a meta-analysis of randomized clinical trials (RCTs) to examine the efficacy and safety of AM therapy for patients with DFUs. <jats:italic>Methods<\/jats:italic>. A literature search of 5 databases was performed to identify RCTs comparing AM therapy to standard therapy (ST) in patients with DFUs. The primary outcome was the complete healing rate and the secondary outcomes mainly included time to complete healing and adverse events. <jats:italic>Results<\/jats:italic>. Nine RCTs involving 897 patients were included. Compared with ST group, patients allocated to AM group had a higher complete healing rate both at 12 weeks (risk ratio <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mfenced open=\"(\" close=\")\"><mml:mrow><mml:mtext>RR<\/mml:mtext><\/mml:mrow><\/mml:mfenced><mml:mo>=<\/mml:mo><mml:mn>1.73<\/mml:mn><\/mml:math>, 95% confidence interval (CI): 1.31 to 2.30) and 16 weeks (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.56<\/mml:mn><\/mml:math>, 95% CI: 1.28 to 1.91), a shorter time to complete healing (mean difference <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mfenced open=\"(\" close=\")\"><mml:mrow><mml:mtext>MD<\/mml:mtext><\/mml:mrow><\/mml:mfenced><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>2.41<\/mml:mn><\/mml:math>; 95% CI: -3.49 to -1.32), and fewer adverse events (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.64<\/mml:mn><\/mml:math>, 95% CI: 0.44 to 0.93). <jats:italic>Conclusion<\/jats:italic>. The present study suggests that AM therapy as an adjuvant treatment could further promote the healing of full-thickness, noninfected, and nonischemia DFUs. AM therapy also has a safety profile. More large well-designed randomized clinical trials with long follow-up duration are needed to further explore the efficacy and safety of AM therapy for DFUs.<\/jats:p>","DOI":"10.1155\/2020\/6245758","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T18:31:32Z","timestamp":1580581892000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-2417","authenticated-orcid":true,"given":"Wentao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou 515041, China"},{"name":"Shantou University Medical College, 22 Xinling Road, Shantou 515041, 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