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This study aimed therefore at evaluating the antifungal potential of ester derivatives of benzoic and cinnamic acids from three <jats:italic>Candida<\/jats:italic> species. The compounds were prepared via Fischer esterification, and the antifungal assay was performed by the microdilution method in 96\u2010well microplates for determining the minimal inhibitory concentrations (MICs). The findings of the antifungal tests revealed that the analogue compound methyl ferulate, methyl <jats:italic>o<\/jats:italic>\u2010coumarate, and methyl biphenyl\u20103\u2010carboxylate displayed an interesting antifungal activity against all <jats:italic>Candida<\/jats:italic> strains tested, with MIC values of 31.25\u201062.5, 62.5\u2010125, and 62.5\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, respectively. A preliminary Structure\u2010Activity Relationship study of benzoic and cinnamic acid derivatives has led to the recognition of some important structural requirements for antifungal activity. The results of molecular docking indicate that the presence of the enoate moiety along with hydroxyl and one methoxy substitution in the phenyl ring has a positive effect on the bioactivity of compound 7 against <jats:italic>Candida albicans<\/jats:italic>. These observations further support the hypothesis that the antifungal activity of compound 7 could be due to its binding to multiple targets, specifically to QR, TS, and ST\u2010PK. Additional experiments are required in the future to test this hypothesis and to propose novel compounds with improved antifungal activity.<\/jats:p>","DOI":"10.1155\/2020\/6345429","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T23:37:00Z","timestamp":1590622620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-0035","authenticated-orcid":false,"given":"Yunierkis","family":"Perez-Castillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-649X","authenticated-orcid":false,"given":"Tamires C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-3489","authenticated-orcid":false,"given":"Alana R.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-351X","authenticated-orcid":false,"given":"Cec\u00edlia R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-978X","authenticated-orcid":false,"given":"Rosana S.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-3012","authenticated-orcid":false,"given":"Jo\u00e3o B. 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