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This study is aimed at identifying the genetic cause of congenital hearing loss in a Chinese Han family. Auditory evaluation before and after cochlear implantation and targeted next-generation sequencing of 140 deafness-related genes were performed for the deaf proband. Compound heterozygous mutations c.3658_3662del (p. E1221Wfs<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>\u2217<\/mml:mo><\/mml:math>23) and c.6177+1G&gt;T were identified in <jats:italic>MYO15A<\/jats:italic> as the only candidate pathogenic mutations cosegregated with the hearing loss in this family. These two variants were absent in 200 normal-hearing Chinese Hans and were classified as likely pathogenic and pathogenic, respectively, based on the ACMG guideline. Our study further expanded the mutation spectrum of <jats:italic>MYO15A<\/jats:italic> as the c.3658_3662del mutation is novel and confirmed that deaf patients with recessive <jats:italic>MYO15A<\/jats:italic> mutations have a good outcome for cochlear implantation.<\/jats:p>","DOI":"10.1155\/2020\/6350479","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T23:31:43Z","timestamp":1592263903000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Targeted Next-Generation Sequencing Identified Compound Heterozygous Mutations in <i>MYO15A<\/i> as the Probable Cause of Nonsyndromic Deafness in a Chinese Han Family"],"prefix":"10.1155","volume":"2020","author":[{"given":"Longhao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China"},{"name":"Ear Institute, Shanghai Jiao Tong University 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