{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:23:03Z","timestamp":1764350583307,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xuzhou Science and Technology Plan Project","award":["KF17097"],"award-info":[{"award-number":["KF17097"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2020,9,14]]},"abstract":"Objective<\/jats:italic>. The present study investigated the clinical features and correlates of poor nighttime sleepiness (PNS) in patients with Parkinson\u2019s disease (PD). Methods<\/jats:italic>. One hundred ten patients with PD (divided into PD-PNS group and PD-nPNS group) and forty-seven controls (nPD-PNS group) were enrolled in this study. Demographic information was collected. Patients were assessed according to the unified Parkinson\u2019s disease rating scale (UPDRS) and Hoehn\u2013Yahr (H&Y) stage scale. Patients were also evaluated according to the Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), rapid eye movement sleep behavior disorder screening questionnaire (RBD-SQ), restless leg syndrome (RLS) diagnosis, Hamilton\u2019s depression scale (HAMD), and Hamilton\u2019s anxiety scale (HAMA). Results<\/jats:italic>. The prevalence of PNS was 55.45% (61\/110) in patients with PD. The PD-PNS group tended to have a longer duration of disease, higher UPDRS-I and UPDRS-III scores, a higher percentage of RLS patients, and higher HAMA and HAMD scores than those of the PD-nPNS group. The PD-PNS group tended to have a higher percentage of RBD and RLS patients and higher HAMA and HAMD scores than those of the nPD-PNS group. Analysis of the PSQI components and PSQI impact factors showed that the PD-PNS group had worse subjective sleep quality (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u2009\u22122.267, P<\/mml:mi><\/mml:math>\u2009=\u20090.023), shorter sleep latency (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u2009\u22122.262, P<\/mml:mi><\/mml:math>\u2009=\u20090.024), fewer sleep medications (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u2009\u22124.170, P<\/mml:mi><\/mml:math>\u2009\u2264\u20090.001), worse daytime functioning (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u2009\u22122.347, P<\/mml:mi><\/mml:math>\u2009=\u20090.019), and an even higher prevalence of increased nocturia (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u20094.447, P<\/mml:mi><\/mml:math>\u2009=\u20090.035), nightmares (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u20097.887, P<\/mml:mi><\/mml:math>\u2009=\u20090.005), and pain (\u03c7<\/jats:italic>2<\/jats:sup>\u2009=\u20099.604, P<\/mml:mi><\/mml:math>\u2009=\u20090.002) than those of the nPD-PNS group. Analysis also indicated that the PSQI global score positively correlated with BMI (r<\/jats:italic>\u2009=\u20090.216, P<\/mml:mi><\/mml:math>\u2009<\u20090.05), H&Y stage (r<\/jats:italic>\u2009=\u20090.223, P<\/mml:mi><\/mml:math>\u2009<\u20090.05), UPDRS-I (r<\/jats:italic>\u2009=\u20090.501, P<\/mml:mi><\/mml:math>\u2009<\u20090.01), UPDRS-III (r<\/jats:italic>\u2009=\u20090.425, P<\/mml:mi><\/mml:math>\u2009<\u20090.01), ESS (r<\/jats:italic>\u2009=\u2009\u22120.296, P<\/mml:mi><\/mml:math>\u2009<\u20090.01), RBD (r<\/jats:italic>\u2009=\u20090.227, P<\/mml:mi><\/mml:math>\u2009<\u20090.05), RLS (r<\/jats:italic>\u2009=\u20090.254, P<\/mml:mi><\/mml:math>\u2009<\u20090.01), HAMA (r<\/jats:italic>\u2009=\u20090.329, P<\/mml:mi><\/mml:math>\u2009<\u20090.01), and HAMD (r<\/jats:italic>\u2009=\u20090.466, P<\/mml:mi><\/mml:math>\u2009<\u20090.01). In the final model, H&Y stage, RLS, UPDRS-III, and HAMD remained associated with the PQSI score (P<\/mml:mi><\/mml:math>\u2009\u2264\u20090.001, P<\/mml:mi><\/mml:math>\u2009\u2264\u20090.001, P<\/mml:mi><\/mml:math>\u2009=\u20090.049, P<\/mml:mi><\/mml:math>\u2009\u2264\u20090.001, respectively). Conclusions<\/jats:italic>. Our data showed that PNS was common in patients with PD. H&Y stage, UPDRS-III, HAMD, and RLS were positively associated with PNS. Attention to the management of motor symptoms, RLS, and depression may be beneficial to nighttime sleep quality in patients with PD.<\/jats:p>","DOI":"10.1155\/2020\/6378673","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T23:32:17Z","timestamp":1600126337000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Features and Correlates of Poor Nighttime Sleepiness in Patients with Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-8148","authenticated-orcid":true,"given":"Xiaoling","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Neurology, Shanghai 8th People\u2019s Hospital, Affiliated to Tongji University, No. 8 Caobao Road, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai 8th People\u2019s Hospital, Affiliated to Tongji University, No. 8 Caobao Road, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-kui","family":"Liu","sequence":"additional","affiliation":[{"name":"Xuzhou Clinical School of Xuzhou Medical University, No. 199 Jiefang Road, Xuzhou 221009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zai-li","family":"Li","sequence":"additional","affiliation":[{"name":"Xuzhou Clinical School of Xuzhou Medical University, No. 199 Jiefang Road, Xuzhou 221009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zai-e","family":"Xin","sequence":"additional","affiliation":[{"name":"Xuzhou Clinical School of Xuzhou Medical University, No. 199 Jiefang Road, Xuzhou 221009, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-0238","authenticated-orcid":true,"given":"Dianshuai","family":"Gao","sequence":"additional","affiliation":[{"name":"Xuzhou Key Laboratory of Neurobiology, Department of 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