{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:58:19Z","timestamp":1790197099780,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800698"],"award-info":[{"award-number":["81800698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31711530025"],"award-info":[{"award-number":["31711530025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Long noncoding RNAs (lncRNAs) have been increasingly recognized as key immune molecules that participate in the pathogenesis of autoimmune diseases. Previous studies have demonstrated that the lncRNA Ifng\u2010AS1, a key scaffold that contributes to the transcription of IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    , depends on T\u2010bet for active transcription in Th1 cells. However, the effect of its human ortholog, IFNG\u2010AS1, on the pathogenesis of rheumatoid arthritis (RA) remains unclear. In this study, we found that the transcript level of lncRNA IFNG\u2010AS1 was increased in the peripheral blood of RA patients. IFNG, as a target gene of IFNG\u2010AS1, was overexpressed and positively correlated with the transcript level of IFNG\u2010AS1 in the RA patients. Our data also showed that the transcript level of T\u2010bet was upregulated and positively correlated with IFNG\u2010AS1 expression. T\u2010bet regulated the transcription of IFNG\u2010AS1 in human CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in vitro. Furthermore, strong positive correlations were observed between the increased transcript level of IFNG\u2010AS1 and the serum level of rheumatoid factor, the erythrocyte sedimentation rate, and the C\u2010reactive protein in RA patients, and patients positive for anticyclic citrullinated peptide antibodies had increased levels of IFNG\u2010AS1. Finally, receiver operating characteristic (ROC) curve analysis suggested that IFNG\u2010AS1 might be a potential biomarker of RA. Taken together, our findings indicated that IFNG\u2010AS1, guided by T\u2010bet, is augmented in the peripheral blood of RA patients and may play a critical role in the pathogenesis of RA by regulating the expression of IFNG.\n                  <\/jats:p>","DOI":"10.1155\/2020\/6401978","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T18:31:33Z","timestamp":1580409093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Elevated Expression of the Long Noncoding RNA IFNG\u2010AS1 in the Peripheral Blood from Patients with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Huiyong","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-4562","authenticated-orcid":false,"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-8546","authenticated-orcid":false,"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-7393","authenticated-orcid":false,"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-1183","authenticated-orcid":false,"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.11.018"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13498"},{"key":"e_1_2_10_3_2","first-page":"144","article-title":"Biomarkers in rheumatoid arthritis, what is new?","volume":"9","author":"Gavrila B. 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