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To explore the effect of different\u2010volume fluid resuscitation (FR) on organ functions in severe acute pancreatitis (SAP) and to elucidate the therapeutic effect and mechanism of <jats:italic>Poria cocos<\/jats:italic> on organ injuries caused by high\u2010volume FR. <jats:italic>Methods<\/jats:italic>. 1. Clinical study: retrospective analysis of thirty\u2010one patients about the effect of titrated fluid resuscitation protocol (TFR) on the occurrence of acute kidney injury (AKI) secondary to SAP. 2. Experimental study: rats (<jats:italic>N<\/jats:italic>\u2009=\u200930) were randomly divided into five groups: sham, model, low\u2010volume FR (1.5\u2009ml\/kg\/h), high\u2010volume FR (10\u2009ml\/kg\/h), and <jats:italic>Poria cocos<\/jats:italic> combined with high\u2010volume FR (10\u2009ml\/kg\/h\u2009+\u2009intraintestinal administration <jats:italic>Poria cocos<\/jats:italic> 5\u2009g\/kg); serum or plasma indicators and histopathologic scores were compared to explore the effect and mechanism of different fluid volumes and <jats:italic>Poria cocos<\/jats:italic> on organ function in SAP. <jats:italic>Results<\/jats:italic>. The occurrence of AKI, fluid volume, and fluid velocity in TFR group was lower than that in the control group. Logistic regression analysis showed that increased Marshall scores and fluid velocity were risk factors for predicting occurrence of AKI in SAP. Low\u2010volume FR decreased the levels of blood urea nitrogen (BUN), serum creatinine (Cr), matrix metalloproteinase (MMP), and pathologic scores of the pancreas and kidney. High\u2010volume FR increased ascites, MMPs, and kidney pathologic scores. <jats:italic>Poria cocos<\/jats:italic> decreased the levels of BUN, Cr, MMPs, and pathologic scores of the pancreas and kidney and increased the arterial oxygen saturation. <jats:italic>Conclusion<\/jats:italic>. TFR\u2010associated lower fluid volume and velocity reduced the occurrence of AKI secondary to SAP. High volume might aggravate AKI via increased MMP release leading to endothelial glycocalyx damage and vascular endothelial dysfunction. <jats:italic>Poria cocos<\/jats:italic> reduced MMP release, relieved glycocalyx damage, and alleviated the pancreas and kidney injury aggravated by high fluid volume in SAP. Therefore, endothelial glycocalyx protection might be a new strategy in the treatment of SAP.<\/jats:p>","DOI":"10.1155\/2020\/6408202","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:07:22Z","timestamp":1602698842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Different\u2010Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect of <i>Poria 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