{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:03:04Z","timestamp":1752282184875,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2020,7,6]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. <jats:italic>Methods<\/jats:italic>. From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study. CKD was defined as creatinine clearance &lt;60\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> according to CKD-EPI equation. Anemia was defined as hemoglobin &lt;12\u2009g\/dL (women) and &lt;13\u2009g\/dL (men). Cox proportional hazards models were used to establish predictors for death. <jats:italic>Results<\/jats:italic>. At baseline, 98 individuals (42.2%) had criteria for CKD and 41 (17.7%) for anemia. During follow-up, 136 patients (58.6%) died. Independently, CKD and anemia were not associated with all-cause mortality. However, when they coexisted, an additional risk was attributed for these patients. Cox proportional hazard models analysis identified systolic blood pressure (hazard ratio, 0.99; 95% confidence interval (CI), 0.98 to 1.00; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:math>), implantable cardioverter-defibrillator (hazard ratio, 0.48; 95% CI, 0.27 to 0.85; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.012<\/mml:mn><\/mml:math>), left anterior fascicular block (hazard ratio, 1.52; 95% CI, 1.08 to 2.13; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>), left ventricular end-diastolic diameter (hazard ratio, 1.04; 95% CI, 1.02 to 1.06; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and serum sodium (hazard ratio, 0.95; 95% CI, 0.92 to 0.99; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.020<\/mml:mn><\/mml:math>) as independent predictors for death. <jats:italic>Conclusions<\/jats:italic>. CKD and anemia are not independent predictors for long-term mortality in CC patients. However, the prognosis is poorer in individuals with both comorbidities.<\/jats:p>","DOI":"10.1155\/2020\/6417874","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:31:24Z","timestamp":1594078284000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-7056","authenticated-orcid":true,"given":"Marcelo Arruda","family":"Nakazone","sequence":"first","affiliation":[{"name":"Postgraduate Division, S\u00e3o Jos\u00e9 do Rio Preto Medical School, 5416 Brigadeiro Faria Lima Ave., CEP 15090-000, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"},{"name":"Hospital de Base, Funda\u00e7\u00e3o Faculdade Regional de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, 5544 Brigadeiro Faria Lima Ave., CEP 15090-000, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-5215","authenticated-orcid":true,"given":"Maur\u00edcio Nassau","family":"Machado","sequence":"additional","affiliation":[{"name":"Hospital de Base, Funda\u00e7\u00e3o Faculdade Regional de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, 5544 Brigadeiro Faria Lima Ave., CEP 15090-000, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-0297","authenticated-orcid":true,"given":"Ana Paula","family":"Otaviano","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Campus Universit\u00e1rio, Ribeir\u00e3o Preto CEP 14048-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-7802","authenticated-orcid":true,"given":"Ana 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