{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:46Z","timestamp":1787017666767,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2020,1,13]]},"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    . To assess the effect of treating chronic hepatitis C virus (HCV) infection with direct acting antiviral drugs (DAAs) on glycemic control in patients with concomitant diabetes mellitus (DM).\n                    <jats:italic>Methods<\/jats:italic>\n                    . We performed a retrospective case-control study in a viral hepatitis ambulatory clinic in Shreveport, Louisiana, during the period 11\/01\/2014 to 12\/31\/2017. All the clinic patient ages 18 years and above with treatment-na\u00efve\/biopsy-proven chronic hepatitis C and DM (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mtext>hemoglobin<\/mml:mtext>\n                      <mml:mtext>\u2009<\/mml:mtext>\n                      <mml:mtext>A<\/mml:mtext>\n                      <mml:mn>1<\/mml:mn>\n                      <mml:mtext>C<\/mml:mtext>\n                      <mml:mtext>\u2009<\/mml:mtext>\n                      <mml:mtext>level<\/mml:mtext>\n                      <mml:mo>\u2265<\/mml:mo>\n                      <mml:mn>6.5<\/mml:mn>\n                      <mml:mi>%<\/mml:mi>\n                    <\/mml:math>\n                    ) who were eligible for treatment were included in the study. Of 118 such patients, 59 were treated with oral DAAs for 8-12 weeks with the goal of achieving a sustained virologic response (SVR). A control group of 59 patients did not receive treatment for their hepatitis C and was followed in the clinic. Patients in the control group did not receive treatment either due to insurance issues or refusal of hepatitis C treatment.\n                    <jats:italic>Results<\/jats:italic>\n                    . Fifty-five of the 59 patients treated with DAAs (93%) achieved a SVR. Six months after treatment completion, their\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mtext>mean<\/mml:mtext>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mtext>SEM<\/mml:mtext>\n                    <\/mml:math>\n                    HbA1C level had decreased by\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mn>1.1<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>0.03<\/mml:mn>\n                      <mml:mi>%<\/mml:mi>\n                    <\/mml:math>\n                    (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    ). Four of the 59 patients treated with DAAs did not achieve a SVR. Their mean HbA1C 6 months after treatment completion had increased by\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mn>0.8<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>0.2<\/mml:mn>\n                      <mml:mi>%<\/mml:mi>\n                    <\/mml:math>\n                    . Furthermore, there was no improvement in HbA1C levels over time in the untreated group (mean HbA1C increase,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mn>0.2<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                      <mml:mi>%<\/mml:mi>\n                    <\/mml:math>\n                    ;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.0001<\/mml:mn>\n                    <\/mml:math>\n                    vs. the treatment group, which had a mean HbA1C decrease of\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                      <mml:mn>0.9<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn>0.2<\/mml:mn>\n                      <mml:mi>%<\/mml:mi>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . This controlled study demonstrated that treatment of chronic hepatitis C with DAAs results in statistically significant and meaningful reductions in hemoglobin A1C levels in patients with coexisting diabetic mellitus if a SVR is achieved.\n                  <\/jats:p>","DOI":"10.1155\/2020\/6438753","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T18:31:33Z","timestamp":1578940293000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Treatment with Direct Acting Antiviral Drugs on Glycemic Control in Patients with Hepatitis C and Diabetes Mellitus"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-7982","authenticated-orcid":true,"given":"Pradeep Kumar","family":"Mada","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Texas Health Presbyterian Hospital, Dallas, TX, USA"},{"name":"Infectious Diseases, Louisiana State University Health Sciences 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