{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:35:52Z","timestamp":1791221752992,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Diagnostic Laboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PPAR Research"],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:p>\n                    Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (\n                    <jats:italic>PPAR\u03b3<\/jats:italic>\n                    ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of\n                    <jats:italic>PPAR\u03b3<\/jats:italic>\n                    expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of\n                    <jats:italic>PPAR\u03b3<\/jats:italic>\n                    -downregulated signaling in psoriasis. We hypothesize that the expression of\n                    <jats:italic>IL17<\/jats:italic>\n                    ,\n                    <jats:italic>STAT3<\/jats:italic>\n                    ,\n                    <jats:italic>FOXP3<\/jats:italic>\n                    , and\n                    <jats:italic>RORC<\/jats:italic>\n                    and\n                    <jats:italic>FOSL1<\/jats:italic>\n                    genes in psoriatic skin is correlated with the level of\n                    <jats:italic>PPAR\u03b3<\/jats:italic>\n                    expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.\n                  <\/jats:p>","DOI":"10.1155\/2020\/6529057","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T08:55:22Z","timestamp":1602406522000},"page":"1-11","source":"Crossref","is-referenced-by-count":17,"title":["The Model of\n                    <i>PPAR\u03b3<\/i>\n                    -Downregulated Signaling in Psoriasis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Vladimir","family":"Sobolev","sequence":"first","affiliation":[{"name":"I. 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